Feitosa Maura Cristina Porto, Lima Vanessa Batista de Sousa, Moita Neto José Machado, Marreiro Dilina do Nascimento
Department of Nutrition, Universidade Federal do Piauí, Teresina, PI, Brazil.
Rev Assoc Med Bras (1992). 2013 Sep-Oct;59(5):429-34. doi: 10.1016/j.ramb.2013.03.003. Epub 2013 Sep 14.
In obesity, the excessive adipose tissue increases the synthesis of inflammatory cytokines, which appear to alter the metabolism of minerals, such as zinc. However, the mechanisms involved remain unclear. This study investigated whether the concentrations of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in plasma can to influence biochemical parameters of zinc in obese women.
Seventy-six pre-menopausal women, aged between 20 and 50 years, were divided into two groups: the case group, composed of obese women (n=37) and the control group, composed of non-obese women (n=39). Analysis of the plasmatic and erythrocytary zinc, and plasmatic cytokines were conducted by flame atomic absorption spectrophotometry and by ELISA, respectively.
The plasmatic zinc and concentrations of IL-6 in plasma did not show significant differences between obese women and controls (p>0.05). The erythrocytary zinc was 36.4 ± 15.0 μg/gHb in the case group, and 45.4 ± 14.3 μg/gHb (p=0.025) in the control group. The concentrations of TNF-α in plasma were 42.0 ± 11.9 pg/mL and 19.0 ± 1.0 pg/mL in obese women and in controls, respectively (p<0.001). The plasmatic zinc had a significant negative correlation with the values of TNFα (r=-0.44, p=0.015).
Obese women presented lower concentrations of erythrocytary zinc than the control group. The study demonstrated a probable influence of the inflammatory process on metabolism of zinc in obese patients.
在肥胖症中，过多的脂肪组织会增加炎性细胞因子的合成，这似乎会改变矿物质（如锌）的代谢。然而，其中涉及的机制仍不清楚。本研究调查了血浆中白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）的浓度是否会影响肥胖女性锌的生化参数。
76名年龄在20至50岁之间的绝经前女性被分为两组：病例组由肥胖女性组成（n = 37），对照组由非肥胖女性组成（n = 39）。分别通过火焰原子吸收分光光度法和酶联免疫吸附测定法对血浆和红细胞中的锌以及血浆细胞因子进行分析。
肥胖女性与对照组之间的血浆锌和血浆中IL-6的浓度没有显著差异（p>0.05）。病例组红细胞锌为36.4±15.0μg/gHb，对照组为45.4±14.3μg/gHb（p = 0.025）。肥胖女性和对照组血浆中TNF-α的浓度分别为42.0±11.9 pg/mL和19.0±1.0 pg/mL（p<0.001）。血浆锌与TNFα值呈显著负相关（r = -0.44，p = 0.015）。
肥胖女性的红细胞锌浓度低于对照组。该研究表明炎症过程可能对肥胖患者的锌代谢有影响。
