Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA.
J Trace Elem Med Biol. 2010 Oct;24(4):271-6. doi: 10.1016/j.jtemb.2010.05.001. Epub 2010 Aug 7.
Metabolic syndrome is a group of disorders involving obesity, insulin resistance, dyslipidemia and hypertension. Obesity is the most crucial risk factor of metabolic syndrome, because it is known to precede other risk factors. Obesity is also associated with disturbances in the metabolism of the trace mineral, zinc. The overall purpose of this study was to investigate the effects of short-term weight loss on plasma zinc and metabolic syndrome risk factors. An 8-week weight loss intervention study was conducted with 90 low-income overweight/obese mothers, whose youngest child was 1-3 years old. Plasma levels of zinc, glucose, insulin, leptin, triglycerides, total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol were measured and compared at weeks 0 and 8 of the weight loss program. At pre-study, plasma zinc was low in 39% and, within normal values in 46%, of obese/overweight mothers. By the end of intervention, plasma zinc rose by 22% and only 5% of the mothers continued to exhibit low plasma zinc. At post-study, the metabolic syndrome risk factors of waist circumference, HDL cholesterol, and diastolic blood pressure (p<0.05) showed significant improvements. Plasma zinc increased by a greater margin (67%) in women with low zinc, as compared to those with normal zinc (18%); weight reduction was similar in both the groups. Finally, changes in % body fat were related negatively with changes in plasma zinc (r=- 0.28, p<0.05). The circulating levels of zinc, as well as the metabolic syndrome components, showed significant improvements in overweight/obese low-income women after weight loss.
代谢综合征是一组涉及肥胖、胰岛素抵抗、血脂异常和高血压的疾病。肥胖是代谢综合征最重要的危险因素，因为它已知先于其他危险因素发生。肥胖还与痕量矿物质锌代谢紊乱有关。本研究的总体目的是研究短期体重减轻对血浆锌和代谢综合征危险因素的影响。对 90 名收入较低的超重/肥胖母亲进行了为期 8 周的减肥干预研究，她们的最小孩子年龄为 1-3 岁。在减肥计划的第 0 周和第 8 周测量并比较了血浆锌、葡萄糖、胰岛素、瘦素、甘油三酯、总胆固醇、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）胆固醇水平。在研究前，39%的肥胖/超重母亲的血浆锌水平较低，而 46%的母亲的血浆锌水平处于正常值范围内。干预结束时，血浆锌水平上升了 22%，只有 5%的母亲继续表现出低血浆锌。在研究后，腰围、HDL 胆固醇和舒张压等代谢综合征危险因素（p<0.05）显著改善。与锌水平正常的女性相比，低锌女性的血浆锌增加了 67%（相比之下，锌水平正常的女性增加了 18%）；两组的体重减轻量相似。最后，体脂百分比的变化与血浆锌的变化呈负相关（r=-0.28，p<0.05）。在减肥后，超重/肥胖的低收入妇女的血浆锌水平以及代谢综合征成分均有显著改善。
