Kotani Kazuhiko, Yamada Toshiyuki, Miyamoto Michiaki, Kario Kazuomi, Ishibashi Shun, Taniguchi Nobuyuki
Department of Clinical Laboratory Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
Heart Vessels. 2012 Sep;27(5):499-504. doi: 10.1007/s00380-011-0182-9. Epub 2011 Sep 3.
Chronic inflammation has received a great deal of attention due to the role it plays in cardiovascular disease (CVD). The cardio-ankle vascular index (CAVI) has recently been developed to evaluate arterial stiffness. This index is independent of blood pressure at the time that it is measured, making it a better measure for clinical studies on the prevention of CVD. Information on the association of serum amyloid A (SAA) with arterial stiffness in relatively healthy subjects is still scarce. The aim of the present study was to investigate the potential correlation between SAA and CAVI in asymptomatic Japanese subjects. In addition to SAA and CAVI, data on smoking status, body mass index, blood pressure, and serum/plasma biochemical indices such as glucose and total cholesterol were collected in 387 nonmedicated and CVD-free adult subjects during a health check examination (male/female 191/196, mean age 61.8 years). Among them, a randomly selected subgroup of 256 subjects (male/female 133/123, mean age 62.4 years) had a full dataset, including low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, and hemoglobin A1c. Among the whole population, CAVI levels were significantly higher in males than in females [mean 8.5 ± (SD 1.1) vs. 8.2 ± 1.1, p < 0.05], while SAA levels were slightly but nonsignificantly higher in females than in males [median 6.4 (interquartile range 4.0-9.3) μg/mL vs. 5.1 (3.5-8.4)]. In a multiple linear regression analysis, CAVI was weakly but significantly, independently, and positively correlated with SAA (β-coefficient 0.200, p < 0.01). The results of the same analyses for the randomly selected subgroup were relatively similar to the findings for the whole population. SAA may be a positive inflammatory factor associated with arterial stiffness, and the clinical relevance and the biological mechanism for this relationship should be established in future studies.
由于慢性炎症在心血管疾病（CVD）中所起的作用，它已受到广泛关注。最近开发了心踝血管指数（CAVI）来评估动脉僵硬度。该指数在测量时与血压无关，使其成为预防CVD临床研究的更好指标。关于相对健康受试者中血清淀粉样蛋白A（SAA）与动脉僵硬度之间关联的信息仍然很少。本研究的目的是调查无症状日本受试者中SAA与CAVI之间的潜在相关性。除了SAA和CAVI外，在一次健康检查中收集了387名未服用药物且无CVD的成年受试者（男性/女性191/196，平均年龄61.8岁）的吸烟状况、体重指数、血压以及血清/血浆生化指标如血糖和总胆固醇的数据。其中，随机选择的256名受试者（男性/女性133/123，平均年龄62.4岁）的亚组拥有完整数据集，包括低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯和糖化血红蛋白。在整个人口中，男性的CAVI水平显著高于女性[平均值8.5±（标准差1.1）对8.2±1.1，p<0.05]，而女性的SAA水平略高于男性，但差异不显著[中位数6.4（四分位间距4.0 - 9.3）μg/mL对5.1（3.5 - 8.4）]。在多元线性回归分析中，CAVI与SAA呈弱但显著、独立且正相关（β系数0.200，p<0.01）。对随机选择亚组进行的相同分析结果与整个人口的研究结果相对相似。SAA可能是与动脉僵硬度相关的一种正向炎症因子，这种关系的临床相关性和生物学机制应在未来研究中确定。
