Department of Pathology and Lab. Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine, 6 Ohio Drive, Suite 202, Lake Success, NY, 11042, USA.
Brain Tumor Pathol. 2012 Jan;29(1):68-72. doi: 10.1007/s10014-011-0062-0. Epub 2011 Sep 3.
Angiocentric glioma (AG) has been formally codified in the revised 2007 WHO Classification of Tumours of the Central Nervous System. AGs characteristically exhibit mixed features of ependymal and diffuse astrocytic differentiation and low proliferation rates, with Ki-67 labeling indices ranging from less than 1 to 5%. A single case with anaplastic recurrence and a labeling index of 10% has been reported. In the present study, we report a series of three AGs (Case 1: 4-year-old girl at right frontal lobe; Case 2: 4-year-old boy at left frontal lobe; Case 3: 9-year-old boy at right temporal lobe). Case 1 with elevated proliferation index (~10%) and increased mitotic activity (six mitoses per 10 high-power fields) on phospho-histone H3 (pHH3) immunostain at presentation, nonetheless, has shown protracted recurrence-free survival after 6 years of follow-up. So far, this is the first report for evaluating the mitotic activity in AGs using pHH3 immunostain.
血管中心性胶质瘤（angiocentric glioma，AG）已在 2007 年修订的世界卫生组织中枢神经系统肿瘤分类中正式编码。AG 的特征是表现出室管膜和弥漫性星形细胞分化的混合特征，增殖率低，Ki-67 标记指数范围为小于 1 至 5%。已经报道了一例具有间变复发和 10%标记指数的病例。在本研究中，我们报告了三例 AG 病例（病例 1：右额叶 4 岁女孩；病例 2：左额叶 4 岁男孩；病例 3：右颞叶 9 岁男孩）。病例 1 在出现时的磷酸化组蛋白 H3（phospho-histone H3，pHH3）免疫染色上显示出较高的增殖指数（~10%）和增加的有丝分裂活性（每 10 个高倍视野中有 6 个有丝分裂），然而，在 6 年的随访后表现出了延长的无复发生存。到目前为止，这是第一个使用 pHH3 免疫染色评估 AG 中有丝分裂活性的报告。
