Dipartimento di Scienze di Sanità Pubblica, Università di Modena e Reggio Emilia, Modena, Italy.
J Mater Sci Mater Med. 2011 Oct;22(10):2329-38. doi: 10.1007/s10856-011-4408-2. Epub 2011 Sep 4.
Hyaluronic acid (HA) has several clinical applications (aesthetic surgery, dermatology, orthopaedics and ophtalmology). Following recent evidence, suggesting antimicrobial and antiviral properties for HA, we investigated its effects on 15 ATCC strains, representative of clinically relevant bacterial and fungal species. The in vitro system employed allowed to assess optical density of broth cultures as a measure of microbial load in a time-dependent manner. The results showed that different microbial species and, sometimes, different strains belonging to the same species, are differently affected by HA. In particular, staphylococci, enterococci, Streptococcus mutans, two Escherichia coli strains, Pseudomonas aeruginosa, Candida glabrata and C. parapsilosis displayed a HA dose-dependent growth inhibition; no HA effects were detected in E. coli ATCC 13768 and C. albicans; S. sanguinis was favoured by the highest HA dose. Therefore, the influence of HA on bacteria and fungi warrants further studies aimed at better establishing its relevance in clinical applications.
透明质酸（HA）在临床上有多种应用（美容外科、皮肤科、矫形科和眼科）。最近的证据表明，HA 具有抗菌和抗病毒特性，因此我们研究了它对 15 株 ATCC 代表临床相关细菌和真菌的影响。所采用的体外系统允许以时间依赖性方式评估肉汤培养物的光密度作为微生物负荷的度量。结果表明，不同的微生物种类，有时甚至是同一物种的不同菌株，对 HA 的影响不同。特别是葡萄球菌、肠球菌、变形链球菌、两种大肠杆菌菌株、铜绿假单胞菌、光滑假丝酵母和近平滑假丝酵母显示出 HA 剂量依赖性的生长抑制；在大肠杆菌 ATCC 13768 和白色念珠菌中未检测到 HA 作用；最高 HA 剂量有利于 S. sanguinis。因此，HA 对细菌和真菌的影响需要进一步研究，以更好地确定其在临床应用中的相关性。
