Department of Infectious Diseases, St. Jude Children’s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105-3678, USA.
Emerg Infect Dis. 2011 Sep;17(9):1624-9. doi: 10.3201/eid1709.110338.
As a result of human-to-pig transmission, pandemic influenza A (H1N1) 2009 virus was detected in pigs soon after it emerged in humans. In the United States, this transmission was quickly followed by multiple reassortment between the pandemic virus and endemic swine viruses. Nine reassortant viruses representing 7 genotypes were detected in commercial pig farms in the United States. Field observations suggested that the newly described reassortant viruses did not differ substantially from pandemic (H1N1) 2009 or endemic strains in their ability to cause disease. Comparable growth properties of reassortant and endemic viruses in vitro supported these observations; similarly, a representative reassortant virus replicated in ferrets to the same extent as did pandemic (H1N1) 2009 and endemic swine virus. These novel reassortant viruses highlight the increasing complexity of influenza viruses within pig populations and the frequency at which viral diversification occurs in this ecologically important viral reservoir.
由于人际传播，甲型 H1N1 流感大流行病毒在人类中出现后不久就在猪群中被检测到。在美国，这种传播很快就伴随着大流行病毒和地方性猪流感病毒之间的多次重配。在美国的商业养猪场中检测到了代表 7 种基因型的 9 种重组病毒。实地观察表明，新描述的重组病毒在引起疾病的能力方面与大流行（H1N1）2009 或地方性毒株没有明显差异。体外重组和地方性病毒的可比生长特性支持了这些观察结果；同样，一种代表性的重组病毒在雪貂中的复制程度与大流行（H1N1）2009 和地方性猪流感病毒相同。这些新型重组病毒突出了猪群中流感病毒的日益复杂性，以及这种在生态上重要的病毒库中病毒多样化发生的频率。
