Reconstitution of catecholamine-sensitive adenylate cyclase. Association of a regulatory component of the enzyme with membranes containing the catalytic protein and beta-adrenergic receptors.

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作者信息

Howlett A C, Sternweis P C, Macik B A, Van Arsdale P M, Gilman A G

出版信息

J Biol Chem. 1979 Apr 10;254(7):2287-95.

PMID:218930

Abstract

摘要

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Reconstitution of catecholamine-sensitive adenylate cyclase. Association of a regulatory component of the enzyme with membranes containing the catalytic protein and beta-adrenergic receptors.

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Hormone-induced guanyl nucleotide binding and activation of adenylate cyclase in the Leydig cell.激素诱导的睾丸间质细胞中鸟苷酸结合及腺苷酸环化酶激活。

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Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium.百日咳毒素底物，即腺苷酸环化酶假定的镍成分，是一种受鸟嘌呤核苷酸和镁调节的αβ异二聚体。

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Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride.铝：氟化物激活腺苷酸环化酶调节成分所必需的物质。

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Activation and attenuation of adenylate cyclase. The role of GTP-binding proteins as macromolecular messengers in receptor--cyclase coupling.腺苷酸环化酶的激活与衰减。GTP结合蛋白作为受体 - 环化酶偶联中大分子信使的作用。

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