通过骨架跃迁设计和合成诺如病毒抑制剂。
Design and synthesis of inhibitors of noroviruses by scaffold hopping.
机构信息
Department of Chemistry, Wichita State University, Wichita, KS 67260, United States.
出版信息
Bioorg Med Chem. 2011 Oct 1;19(19):5749-55. doi: 10.1016/j.bmc.2011.08.032. Epub 2011 Aug 22.
Abstract
A scaffold hopping strategy was employed to identify new chemotypes that inhibit noroviruses. The replacement of the cyclosulfamide scaffold by an array of heterocyclic scaffolds lead to the identification of additional series of compounds that possessed anti-norovirus activity in a cell-based replicon system.
摘要
采用支架跳跃策略来鉴定抑制诺如病毒的新型化学型。通过用一系列杂环支架替代环硫酰胺支架，在基于细胞的复制子系统中鉴定到了具有抗诺如病毒活性的额外系列化合物。
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