Ganzinger Matthias, Noack Tino, Diederichs Sven, Longerich Thomas, Knaup Petra
Department of Medical Informatics, University of Heidelberg, Germany.
Stud Health Technol Inform. 2011;169:867-71.
In biomedical research, a variety of data like clinical, genetic, expression of coding or non-coding ribonucleic acid (RNA) transcripts, or proteomic data are processed to gain new insights into diseases and therapies. In transregional research networks, geographically distributed projects work on comparable research questions with data from different resources and in different formats. Providing an information platform that integrates the data of the projects can enable cross-project analysis and provides an overview of available data and resources (tissue, blood, etc.). For a German liver cancer research network consisting of 22 individual projects, we develop the integrated information platform pelican - platform enhancing liver cancer networked research. In our generic approach, data are made available to the research network by standardized data services based on technologies provided by the cancer Biomedical Informatics Grid (caBIG). It has shown that publishing service metadata in a corresponding repository is a major prerequisite for automated discovery, integration, and conversion of data records and data services. We identified data confidentiality and intellectual property considerations as major challenges while establishing such an integrated information platform. As a first result we implemented a working prototype to validate our approach.
在生物医学研究中，会处理各种数据，如临床数据、基因数据、编码或非编码核糖核酸（RNA）转录本的表达数据，或蛋白质组学数据，以获得对疾病和治疗方法的新见解。在跨区域研究网络中，地理位置分散的项目针对类似的研究问题开展工作，使用来自不同来源、不同格式的数据。提供一个整合项目数据的信息平台，可以实现跨项目分析，并提供可用数据和资源（组织、血液等）的概述。对于一个由22个独立项目组成的德国肝癌研究网络，我们开发了集成信息平台鹈鹕——增强肝癌网络研究的平台。在我们的通用方法中，基于癌症生物医学信息网格（caBIG）提供的技术，通过标准化数据服务将数据提供给研究网络。结果表明，在相应的存储库中发布服务元数据是数据记录和数据服务自动发现、集成及转换的主要前提。我们发现在建立这样一个集成信息平台时，数据保密和知识产权方面的考虑是主要挑战。作为第一个成果，我们实现了一个工作原型来验证我们的方法。
