Department of Surgery, University of Verona, Verona, Italy.
Pancreatology. 2011;11(4):383-9. doi: 10.1159/000330212. Epub 2011 Aug 30.
BACKGROUND/AIMS: Pancreatic tumors in children and adolescents are uncommon. The aim of the present paper was to analyze short- and long-term outcomes after surgical treatment of primary pancreatic neoplasms in children and adolescents at a single high-volume center for pancreatic diseases.
Retrospective review of medical records and pathology reports of patients younger than 18 years who underwent surgery at Verona University Hospital from 1990 through 2010.
The study population consisted of 20 patients. Abdominal pain and palpable mass were the most common presenting symptoms. No patient had a locally advanced, unresectable or metastatic disease. Complete resection (R0) was achieved in 19 patients. There was no postoperative mortality, but postoperative complications occurred in 5 cases (25%). Histological examination showed 12 solid pseudopapillary tumors, 5 neuroendocrine tumors, 2 cystadenomas and 1 epithelial malignant tumor. At a median follow-up of 49.5 months (range: 7-234), there was no tumor recurrence. Postoperative diabetes was diagnosed in 1 patient and 4 other patients developed pancreatic exocrine insufficiency.
In the setting of a high-volume surgical center, radical resection of pancreatic tumors in children and adolescents is associated with acceptable postoperative morbidity and favorable long-term outcome.
背景/目的：儿童和青少年的胰腺肿瘤并不常见。本文旨在分析单一大容量胰腺疾病中心对儿童和青少年胰腺原发性肿瘤进行手术治疗后的短期和长期结果。
回顾性分析了 1990 年至 2010 年期间在维罗纳大学医院接受手术的年龄小于 18 岁的患者的病历和病理报告。
研究人群包括 20 名患者。腹痛和可触及的肿块是最常见的症状。没有患者患有局部晚期、不可切除或转移性疾病。19 名患者实现了完全切除（R0）。没有术后死亡，但 5 例（25%）出现术后并发症。组织学检查显示 12 例实性假乳头状瘤、5 例神经内分泌肿瘤、2 例囊腺瘤和 1 例上皮恶性肿瘤。在中位随访 49.5 个月（范围：7-234）期间，没有肿瘤复发。1 例患者术后诊断为糖尿病，4 例其他患者出现胰腺外分泌功能不全。
在大容量手术中心，儿童和青少年胰腺肿瘤的根治性切除与可接受的术后发病率和良好的长期结果相关。
