Cen Dong, Chen Jiang, Li Zheyong, Zhao Jie, Cai Xiujun
Department of General Surgery, Institute of Minimally Invasive Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
PLoS One. 2017 Nov 14;12(11):e0187588. doi: 10.1371/journal.pone.0187588. eCollection 2017.
Pancreatic neuroendocrine tumor (PNET) comprises 1-2% of all pancreatic tumors, but its incidence is increasing. Although many studies have investigated the correlation between cytokeratin 19 (CK-19) and PNET, the prognostic significance of CK-19 expression in PNET is inconclusive.
Eligible studies were retrieved from Pubmed, Elsevier, Embase, Cochrane Library and Web of Science databases. All relevant data were extracted to analyze the relationship between CK-19 and PNET. We utilized a fixed or random effects model to calculate the pooled odds ratio (OR) with 95% confidence intervals (CI).
Pooled data indicated CK-19 expression was significantly associated with poor 3- and 5-year overall survival (OS) for PNET, but not for 1-year overall survival. Additionally, positive CK-19 expression was correlated with large tumor size, advanced differentiation grade in World Health Organization-2010 (WHO-2010) and WHO-2004, vascular invasion, lymph node metastasis and liver metastasis.
Positive CK-19 expression can be used as a predictor of poor prognosis of PNET.
胰腺神经内分泌肿瘤（PNET）占所有胰腺肿瘤的1%-2%，但其发病率正在上升。尽管许多研究调查了细胞角蛋白19（CK-19）与PNET之间的相关性，但CK-19在PNET中表达的预后意义尚无定论。
从PubMed、Elsevier、Embase、Cochrane图书馆和科学网数据库中检索符合条件的研究。提取所有相关数据以分析CK-19与PNET之间的关系。我们采用固定效应或随机效应模型计算合并比值比（OR）及95%置信区间（CI）。
汇总数据表明，CK-19表达与PNET患者3年和5年总生存期（OS）较差显著相关，但与1年总生存期无关。此外，CK-19阳性表达与肿瘤体积大、2010年世界卫生组织（WHO-2010）和2004年WHO的高分化等级、血管侵犯、淋巴结转移和肝转移相关。
CK-19阳性表达可作为PNET预后不良的预测指标。
