Biswas Sayantan, Raman Rajiv, Koluthungan Vaitheeswaran, Sharma Tarun
Elite School of Optometry, Sankara Nethralaya, Chennai, Tamil Nadu, India.
J Prev Med Public Health. 2011 Jul;44(4):157-66. doi: 10.3961/jpmph.2011.44.4.157.
This study was conducted to show the intraocular pressure (IOP) distribution and the factors affecting IOP in subjects with type 2 diabetes mellitus (DM) in India.
We measured the anthropometric and biochemical parameters for confirmed type 2 DM patients. A comprehensive ocular examination was performed for 1377 subjects aged > 40 years and residing in Chennai.
A significant difference in IOP (mean ± standard deviation) was found between men and women (14.6 ± 2.9 and 15.0 ± 2.8 mmHg, p = 0.005). A significantly elevated IOP was observed among smokers, subjects with systemic hypertension and women with clinically significant macular edema (CSME). After a univariate analysis, factors associated significantly with higher IOP were elevated systolic blood pressure, elevated resting pulse rate and thicker central corneal thickness (CCT). In women, elevated glycosylated hemoglobin was associated with a higher IOP. After adjusting for all variables, the elevated resting pulse rate and CCT were found to be associated with a higher IOP.
Systemic hypertension, smoking, pulse rate and CCT were associated with elevated intraocular pressure in type 2 DM. Women with type 2 DM, especially those with CSME, were more prone to have an elevated IOP.
本研究旨在展示印度2型糖尿病（DM）患者的眼内压（IOP）分布情况以及影响IOP的因素。
我们测量了确诊的2型糖尿病患者的人体测量学和生化参数。对居住在金奈的1377名年龄大于40岁的受试者进行了全面的眼科检查。
男性和女性之间的IOP（平均值±标准差）存在显著差异（分别为14.6±2.9和15.0±2.8 mmHg，p = 0.005）。在吸烟者、患有系统性高血压的受试者以及患有临床显著性黄斑水肿（CSME）的女性中观察到IOP显著升高。经过单因素分析，与较高IOP显著相关的因素包括收缩压升高、静息脉率升高和中央角膜厚度（CCT）增厚。在女性中，糖化血红蛋白升高与较高的IOP相关。在对所有变量进行调整后，发现静息脉率升高和CCT与较高的IOP相关。
系统性高血压、吸烟、脉率和CCT与2型糖尿病患者的眼内压升高有关。2型糖尿病女性，尤其是患有CSME的女性，更易出现眼内压升高。
