Glaucoma Project, Vision Research Foundation, Sankara Nethralaya, Chennai, India.
Ophthalmology. 2010 Apr;117(4):700-4. doi: 10.1016/j.ophtha.2009.09.025. Epub 2010 Jan 15.
To evaluate the characteristics of central corneal thickness (CCT) and its association with age, gender, and intraocular pressure in rural and urban South Indian populations.
Population-based cross-sectional study.
Seven thousand seven hundred seventy-four subjects (rural-to-urban ratio, 3924:3850) aged 40 years and older were examined at a dedicated facility in the base hospital.
All subjects underwent a complete ophthalmic examination that included CCT measurements with an ultrasonic pachymeter and applanation tonometry.
Central corneal thickness.
Of the 7774 subjects examined, 974 had undergone cataract surgery and were excluded. The remaining 6800 were bilaterally phakic, of which 46 were excluded (17 glaucoma subjects receiving treatment, 12 with corneal pathologic features and 17 with incomplete data) and 6754 subjects data were analyzed. The mean CCT for the population was 511.4+/-33.5 microm, and CCT in males (515.6+/-33.8 microm) was significantly (P = 0.0001) greater than females (508.0+/-32.8 microm). The CCT was significantly greater (by 18 microm) in the urban population and decreased with age in both genders (P<0.0001). The decrease per decade was 4.34 microm (95% confidence interval [CI], 3.24-5.44) in the rural population and 2.41 microm (95% CI, 1.25-3.53) in the urban population. A 100-microm increase in CCT was associated with a 1.96-mmHg increase in intraocular pressure in the rural population, versus 2.45 mmHg for every 100 microm in the urban population.
In this population-based study, females and subjects living in a rural area had thinner corneas. A negative association with age and a positive association with intraocular pressure were seen. These findings will have implications in the diagnosis and management of glaucoma in this population.
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.
评估中印南部农村和城市人群中央角膜厚度（CCT）的特征及其与年龄、性别和眼压的关系。
基于人群的横断面研究。
在基地医院的专门设施中检查了 7774 名年龄在 40 岁及以上的受试者（城乡比例为 3924:3850）。
所有受试者均接受全面眼科检查，包括使用超声角膜测厚仪和压平眼压计测量 CCT。
中央角膜厚度。
在接受检查的 7774 名受试者中，有 974 名接受过白内障手术，被排除在外。其余 6800 名受试者均为双眼白内障，其中 46 名因（17 名接受治疗的青光眼患者、12 名有角膜病理特征和 17 名数据不完整）被排除在外，对 6754 名受试者的数据进行了分析。该人群的平均 CCT 为 511.4+/-33.5 微米，男性（515.6+/-33.8 微米）的 CCT 显著大于女性（508.0+/-32.8 微米）（P = 0.0001）。城市人群的 CCT 显著较高（高 18 微米），且男女 CCT 均随年龄增长而降低（P<0.0001）。农村人口每十年下降 4.34 微米（95%置信区间[CI]，3.24-5.44），城市人口下降 2.41 微米（95% CI，1.25-3.53）。农村人群 CCT 每增加 100 微米，眼压增加 1.96mmHg，而城市人群每增加 100 微米，眼压增加 2.45mmHg。
在这项基于人群的研究中，女性和生活在农村地区的受试者角膜较薄。与年龄呈负相关，与眼压呈正相关。这些发现将对该人群青光眼的诊断和治疗产生影响。
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