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糖尿病患者的膀胱功能障碍。

Bladder dysfunction in patients with diabetes.

机构信息

Bladder Health and Reconstructive Urology Institute, Memorial Hospital Miramar, 1951 Southwest 172nd Avenue, Suite #408, Miramar, FL 33029, USA.

出版信息

Curr Urol Rep. 2011 Dec;12(6):419-26. doi: 10.1007/s11934-011-0214-0.

DOI:10.1007/s11934-011-0214-0
PMID:21894526
Abstract

With diabetes mellitus (DM) reaching epidemic proportions, the identification of voiding dysfunction as a common and burdensome complication of this disease is critical. Research into diabetic voiding dysfunction significantly lags behind other complications of DM, such as retinopathy and nephropathy. Recent studies have revealed that DM predisposes patients to a wide range of lower urinary tract dysfunction, from the classic diabetic cystopathy of incomplete emptying to urgency incontinence. In this review, we discuss the current concepts of diabetic voiding dysfunction with a critical analysis of the available evidence.

摘要

随着糖尿病(DM)发病率的上升,识别排尿功能障碍作为该疾病的常见且负担沉重的并发症至关重要。与糖尿病的其他并发症(如视网膜病变和肾病)相比,对糖尿病性排尿功能障碍的研究明显滞后。最近的研究表明,DM 使患者易患多种下尿路功能障碍,从经典的不完全排空性糖尿病膀胱病变到急迫性尿失禁。在这篇综述中,我们讨论了糖尿病性排尿功能障碍的当前概念,并对现有证据进行了批判性分析。

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Bladder dysfunction in patients with diabetes.糖尿病患者的膀胱功能障碍。
Curr Urol Rep. 2011 Dec;12(6):419-26. doi: 10.1007/s11934-011-0214-0.
2
Diabetes mellitus and female lower urinary tract symptoms: a review.糖尿病与女性下尿路症状:综述
Neurourol Urodyn. 2008;27(5):362-7. doi: 10.1002/nau.20533.
3
[Urodynamic study of lower urinary tract. VII. Clinical studies of diabetic cystopathy (author's transl)].下尿路尿动力学研究。VII. 糖尿病性膀胱病的临床研究(作者译)
Nihon Hinyokika Gakkai Zasshi. 1979 Apr;70(4):392-402. doi: 10.5980/jpnjurol1928.70.4_392.
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Diabetic bladder dysfunction: current translational knowledge.糖尿病性膀胱功能障碍:当前的转化知识。
J Urol. 2009 Dec;182(6 Suppl):S18-26. doi: 10.1016/j.juro.2009.08.070.
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Diabetic cystopathy: A review.糖尿病性膀胱病:综述。
J Diabetes. 2015 Jul;7(4):442-7. doi: 10.1111/1753-0407.12272. Epub 2015 Mar 24.
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Pudendal neuromodulation improves voiding efficiency in diabetic rats.阴部神经调节可提高糖尿病大鼠的排尿效率。
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[Diabetic vesicourethral dysfunction].[糖尿病性膀胱尿道功能障碍]
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Urinary symptoms and female sexual dysfunction in women with type 1 diabetes: the role of depression.1 型糖尿病女性的尿症状和女性性功能障碍:抑郁的作用。
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Male Akita mice develop signs of bladder underactivity independent of NLRP3 as a result of a decrease in neurotransmitter release from efferent neurons.

本文引用的文献

1
Role of Purinergic Signaling in Voiding Dysfunction.嘌呤能信号在排尿功能障碍中的作用。
Curr Bladder Dysfunct Rep. 2010 Aug 26;5(4):219-224. doi: 10.1007/s11884-010-0063-6.
2
Diabetes and benign prostatic hyperplasia/lower urinary tract symptoms--what do we know?糖尿病与良性前列腺增生/下尿路症状——我们了解多少?
J Urol. 2009 Dec;182(6 Suppl):S32-7. doi: 10.1016/j.juro.2009.07.088.
3
Animal models of diabetic uropathy.糖尿病性尿路病的动物模型。
雄性秋田犬小鼠由于传出神经元神经递质释放减少,出现膀胱活动低下的迹象,与 NLRP3 无关。
Am J Physiol Renal Physiol. 2023 Jul 1;325(1):F61-F72. doi: 10.1152/ajprenal.00284.2022. Epub 2023 May 11.
4
Urinary ATP Levels Are Controlled by Nucleotidases Released from the Urothelium in a Regulated Manner.尿ATP水平受尿路上皮以调节方式释放的核苷酸酶控制。
Metabolites. 2022 Dec 24;13(1):30. doi: 10.3390/metabo13010030.
5
Inflammation triggered by the NLRP3 inflammasome is a critical driver of diabetic bladder dysfunction.由NLRP3炎性小体引发的炎症是糖尿病膀胱功能障碍的关键驱动因素。
Front Physiol. 2022 Nov 25;13:920487. doi: 10.3389/fphys.2022.920487. eCollection 2022.
6
An evaluation of lower urinary tract symptoms in diabetic patients: a cross-sectional study.糖尿病患者下尿路症状评估:一项横断面研究。
BMC Urol. 2022 Nov 10;22(1):178. doi: 10.1186/s12894-022-01133-1.
7
Potential role of oxidative stress in the pathogenesis of diabetic bladder dysfunction.氧化应激在糖尿病膀胱功能障碍发病机制中的潜在作用。
Nat Rev Urol. 2022 Oct;19(10):581-596. doi: 10.1038/s41585-022-00621-1. Epub 2022 Aug 16.
8
Anti-inflammation properties of resveratrol in the detrusor smooth muscle of the diabetic rat.白藜芦醇对糖尿病大鼠逼尿肌平滑肌的抗炎作用。
Int Urol Nephrol. 2022 Nov;54(11):2833-2843. doi: 10.1007/s11255-022-03334-x. Epub 2022 Aug 9.
9
Diabetic bladder dysfunction progresses from an overactive to an underactive phenotype in a type-1 diabetic mouse model (Akita female mouse) and is dependent on NLRP3.1 型糖尿病小鼠模型(Akita 雌性小鼠)中糖尿病膀胱功能障碍从过度活跃表型进展为不活跃表型,并且依赖于 NLRP3。
Life Sci. 2022 Jun 15;299:120528. doi: 10.1016/j.lfs.2022.120528. Epub 2022 Apr 2.
10
IR-61 Improves Voiding Function Mitochondrial Protection in Diabetic Rats.IR-61改善糖尿病大鼠的排尿功能及线粒体保护作用。
Front Pharmacol. 2021 Apr 14;12:608637. doi: 10.3389/fphar.2021.608637. eCollection 2021.
J Urol. 2009 Dec;182(6 Suppl):S8-13. doi: 10.1016/j.juro.2009.07.084.
4
Diabetes mellitus and urinary tract infection: epidemiology, pathogenesis and proposed studies in animal models.糖尿病与尿路感染:流行病学、发病机制及动物模型研究建议。
J Urol. 2009 Dec;182(6 Suppl):S51-6. doi: 10.1016/j.juro.2009.07.090.
5
Urine production and bladder diary measurements in women with type 2 diabetes mellitus and their relation to lower urinary tract symptoms and voiding dysfunction.2 型糖尿病女性的尿生成和膀胱日记测量及其与下尿路症状和排尿功能障碍的关系。
Neurourol Urodyn. 2010 Mar;29(3):354-8. doi: 10.1002/nau.20778.
6
Sacral neuromodulation in diabetic patients: success and complications in the treatment of voiding dysfunction.糖尿病患者的骶神经调节:治疗排尿功能障碍的成功率和并发症。
Neurourol Urodyn. 2010 Apr;29(4):578-81. doi: 10.1002/nau.20791.
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Urodynamic findings in female diabetic patients with and without overactive bladder symptoms.女性糖尿病患者伴或不伴膀胱过度活动症的尿动力学研究结果。
Neurourol Urodyn. 2010 Mar;29(3):424-7. doi: 10.1002/nau.20727.
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Effect of intensive glycemic control and diabetes complications on lower urinary tract symptoms in men with type 1 diabetes: Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study.强化血糖控制及糖尿病并发症对1型糖尿病男性下尿路症状的影响:糖尿病控制与并发症试验/糖尿病干预与并发症流行病学(DCCT/EDIC)研究
Diabetes Care. 2009 Apr;32(4):664-70. doi: 10.2337/dc07-2375. Epub 2009 Jan 26.
10
Investigation of urodynamic characteristics and bladder sensory function in the early stages of diabetic bladder dysfunction in women with type 2 diabetes.2型糖尿病女性糖尿病膀胱功能障碍早期尿动力学特征及膀胱感觉功能的研究
J Urol. 2009 Jan;181(1):198-203. doi: 10.1016/j.juro.2008.09.021. Epub 2008 Nov 14.