Ophthalmology Department, Leicester Royal Infirmary , Infirmary Square, Leicester, UK.
Ocul Immunol Inflamm. 2011 Oct;19(5):373-5. doi: 10.3109/09273948.2011.602500. Epub 2011 Sep 6.
Multiple sclerosis is associated with iridocyclitis, intermediate uveitis, retinal periphlebitis, and optic neuritis. The periphlebitis is known to be rarely sight-threatening as a result of the sequelae of retinal neovascularization.
This is a rare case of bilateral rubeosis iridis and rubeotic glaucoma in the setting of a branch retinal vein occlusion, widespread peripheral periphlebitis, and angiographic peripheral closure associated with "clinically definite" multiple sclerosis.
The case illustrates the extreme end of the spectrum of peripheral retinal ischemia and neovascularization associated with demyelinating disease, which can present as rubeotic glaucoma. Such patients require a proactive approach to inflammation, neovascularization, and raised intraocular pressure, including systemic immunosuppression, photocoagulation, and augmented trabeculectomy, respectively. As with other causes of peripheral ischemia, a favorable visual outcome can often be achieved using this strategy.
译文：未标注：多发性硬化症与虹膜睫状体炎、中间葡萄膜炎、视网膜血管周围炎和视神经炎有关。已知视网膜新生血管化的后遗症很少导致血管周围炎视力威胁。
病例：这是一例罕见的双侧虹膜新生血管和新生血管性青光眼病例，其发生于视网膜分支静脉阻塞、广泛的外周血管周围炎以及与“临床明确”多发性硬化症相关的血管造影外周闭塞。
讨论：该病例说明了与脱髓鞘疾病相关的周边视网膜缺血和新生血管形成的极端情况，可表现为新生血管性青光眼。此类患者需要积极治疗炎症、新生血管形成和眼压升高，分别包括全身免疫抑制、光凝和增强小梁切除术。与其他周边缺血的原因一样，通过这种策略通常可以获得良好的视力预后。
