Department of Pharmacy, West China Second University Hospital, Sichuan, China.
Trop Med Int Health. 2011 Dec;16(12):1474-82. doi: 10.1111/j.1365-3156.2011.02871.x. Epub 2011 Sep 7.
To determine the efficacy and safety of zinc supplementary in children, adults and pregnant women with HIV infection.
We conducted a comprehensive search in Medline, Embase, the Cochrane Library, CBM, VIP and CNKI. Only randomized controlled trials conducted subsequent to the introduction of zinc supplementation were included in this systematic review. Two reviewers assessed and extracted data for analysis.
Six trials with a total of 1009 participants were included. The findings in this review suggested a benefit of zinc supplementation in reducing opportunistic infection for both adults and children with HIV infection. In terms of increase in zinc level and CD4 counts, however, only adults with HIV infection benefited. For other outcomes, such as viral load, mortality, mother-to-child transmission of HIV and foetal outcomes, zinc supplementation conferred no benefit over placebo. No adverse event related to zinc supplementation was found in all the included trials.
Based on the current evidence, zinc supplementation seems to be beneficial in adult patients with HIV infection in some aspects. More research is needed in children and pregnant women. The influence of zinc dose, duration and usage of antiretroviral medicine also requires further investigation.
评估在感染 HIV 的儿童、成人和孕妇中补锌的疗效和安全性。
我们对 Medline、Embase、Cochrane 图书馆、CBM、VIP 和 CNKI 进行了全面检索。本系统评价仅纳入补锌后进行的随机对照试验。两名评价者评估并提取数据进行分析。
共纳入 6 项试验，总计 1009 名参与者。本综述的结果提示补锌可减少 HIV 感染者的机会性感染。然而，只有 HIV 感染的成年患者在提高锌水平和 CD4 计数方面受益。对于其他结局，如病毒载量、死亡率、HIV 母婴传播和胎儿结局，补锌与安慰剂相比无益处。所有纳入试验均未发现与补锌相关的不良事件。
基于现有证据，补锌似乎对某些方面的 HIV 感染成年患者有益。还需要更多针对儿童和孕妇的研究。锌剂量、补锌持续时间和抗逆转录病毒药物的使用等因素的影响也需要进一步研究。
