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人类分枝杆菌病的小鼠模型是否相关？遗传学说是：“是！”。

Are mouse models of human mycobacterial diseases relevant? Genetics says: 'yes!'.

机构信息

Central Institute for Tuberculosis, Moscow, Russia.

出版信息

Immunology. 2011 Oct;134(2):109-15. doi: 10.1111/j.1365-2567.2011.03472.x.

DOI:10.1111/j.1365-2567.2011.03472.x
PMID:21896006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3194219/
Abstract

Relevance and accuracy of experimental mouse models of tuberculosis (TB) are the subject of constant debate. This article briefly reviews genetic aspects of this problem and provides a few examples of mycobacterial diseases with similar or identical genetic control in mice and humans. The two species display more similarities than differences regarding both genetics of susceptibility/severity of mycobacterial diseases and the networks of protective and pathological immune reactions. In the opinion of the author, refined mouse models of mycobacterial diseases are extremely useful for modelling the corresponding human conditions, if genetic diversity is taken into account.

摘要

结核分枝杆菌（TB）实验小鼠模型的相关性和准确性一直是争论的主题。本文简要回顾了这一问题的遗传方面，并提供了一些在小鼠和人类中具有相似或相同遗传控制的分枝杆菌病的例子。这两个物种在易感性/严重程度的分枝杆菌病的遗传以及保护性和病理性免疫反应的网络方面显示出更多的相似之处，而不是差异。作者认为，如果考虑遗传多样性，那么分枝杆菌病的改良小鼠模型对于模拟相应的人类疾病非常有用。

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引用本文的文献

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PLoS One. 2020 Sep 24;15(9):e0239668. doi: 10.1371/journal.pone.0239668. eCollection 2020.
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Certain Polymorphisms in SP110 Gene Confer Susceptibility to Tuberculosis: A Comprehensive Review and Updated Meta-Analysis.SP110基因的某些多态性赋予结核病易感性：一项全面综述和更新的荟萃分析。
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PLoS Genet. 2015 Nov 30;11(11):e1005672. doi: 10.1371/journal.pgen.1005672. eCollection 2015 Nov.
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Mycobacterial receptor, Clec4d (CLECSF8, MCL), is coregulated with Mincle and upregulated on mouse myeloid cells following microbial challenge.分枝杆菌受体Clec4d（CLECSF8，MCL）与Mincle共同调节，在微生物攻击后小鼠髓样细胞上上调。
Eur J Immunol. 2016 Feb;46(2):381-9. doi: 10.1002/eji.201545858. Epub 2015 Dec 8.
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本文引用的文献

1
IRF8 mutations and human dendritic-cell immunodeficiency.IRF8 突变与人类树突状细胞免疫缺陷。
N Engl J Med. 2011 Jul 14;365(2):127-38. doi: 10.1056/NEJMoa1100066. Epub 2011 Apr 27.
2
[A locus involved in tuberculosis infection control in mice locates in the proximal part of the H2 complex].[小鼠中参与结核感染控制的一个基因座位于H2复合体的近端]
Mol Biol (Mosk). 2011 Jan-Feb;45(1):68-76.
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Development of new vaccines and drugs for TB: limitations and potential strategic errors.开发新的结核病疫苗和药物：局限性和潜在的战略错误。
Future Microbiol. 2011 Feb;6(2):161-77. doi: 10.2217/fmb.10.168.
4
Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease.家族性 X 连锁易感性结核分枝杆菌病中选择性影响巨噬细胞的种系 CYBB 突变。
Nat Immunol. 2011 Mar;12(3):213-21. doi: 10.1038/ni.1992. Epub 2011 Jan 30.
5
Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases.人类自身免疫性疾病中 CD4(+)CD25(+)FOXP3(+)调节性 T 细胞功能障碍的调节机制。
Nat Rev Immunol. 2010 Dec;10(12):849-59. doi: 10.1038/nri2889.
6
SP110 as a novel susceptibility gene for Mycobacterium avium subspecies paratuberculosis infection in cattle.SP110 作为牛分枝杆菌副结核亚种感染的一个新的易感性基因。
J Dairy Sci. 2010 Dec;93(12):5950-8. doi: 10.3168/jds.2010-3340.
7
[Study on relation between Sp110 gene polymorphism and tuberculosis genetic susceptibility of Chongqing Han People].[重庆汉族人群Sp110基因多态性与结核病遗传易感性的关系研究]
Wei Sheng Yan Jiu. 2010 Sep;39(5):540-4.
8
In vivo expression of innate immunity markers in patients with Mycobacterium tuberculosis infection.结核分枝杆菌感染患者固有免疫标志物的体内表达。
BMC Infect Dis. 2010 Aug 18;10:243. doi: 10.1186/1471-2334-10-243.
9
Host genetics in granuloma formation: human-like lung pathology in mice with reciprocal genetic susceptibility to M. tuberculosis and M. avium.宿主遗传学在肉芽肿形成中的作用：对结核分枝杆菌和鸟分枝杆菌具有相互遗传易感性的小鼠具有类似人类的肺部病理学。
PLoS One. 2010 May 6;5(5):e10515. doi: 10.1371/journal.pone.0010515.
10
Animal models of tuberculosis.结核病动物模型。
Eur J Immunol. 2009 Aug;39(8):2011-4. doi: 10.1002/eji.200939542.