Annweiler Cédric, Souberbielle Jean-Claude, Schott Anne-Marie, de Decker Laure, Berrut Gilles, Beauchet Olivier
Département de médecine interne et gériatrie, Centre hospitalier universitaire d'Angers, France.
Geriatr Psychol Neuropsychiatr Vieil. 2011 Sep;9(3):259-67. doi: 10.1684/pnv.2011.0288.
Vitamin D is a secosteroid hormone. Vitamin D receptors are present in the majority of body tissues. The manifestations of hypovitaminosis D - linked to dysfunction of target tissues - are various, including osteoporosis, cancer, tuberculosis, hypertension, multiple sclerosis, depression, dementia, sarcopenia, propensity to fall… The serum 25-hydroxyvitamin D threshold value to avoid these adverse health events is around 30 ng/mL. Only 15% of the elderly reach this target concentration. For the remaining 85% with no supplements, the severity of hypovitaminosis D appears to be a biomarker of chronic diseases and of frailty. Conversely, the supplementation for correction of hypovitaminosis D positively impacts bone and non-bone morbidities - such as risks of falls and fractures - and reduces the mortality rate. A daily intake of at least 800-1,000 IU supplemental vitamin D(3) per day is the key.
维生素D是一种类固醇激素。人体大多数组织中都存在维生素D受体。与靶组织功能障碍相关的维生素D缺乏症表现多样，包括骨质疏松症、癌症、结核病、高血压、多发性硬化症、抑郁症、痴呆症、肌肉减少症、跌倒倾向……避免这些不良健康事件的血清25-羟维生素D阈值约为30 ng/mL。只有15%的老年人达到这一目标浓度。对于其余85%未补充维生素D的人来说，维生素D缺乏症的严重程度似乎是慢性病和虚弱的生物标志物。相反，补充维生素D以纠正维生素D缺乏症对骨骼和非骨骼疾病（如跌倒和骨折风险）有积极影响，并降低死亡率。关键是每天至少摄入800-1000国际单位的补充维生素D(3)。
