Department of Public Health and Preventive Medicine, Oregon Health and Science University School of Medicine, Portland, OR, USA.
Mol Nutr Food Res. 2010 Aug;54(8):1114-26. doi: 10.1002/mnfr.200900574.
The hypothesis that vitamin D is inversely associated with multiple health outcomes has been studied in the Harvard cohorts, including the Nurses' Health Study I (n=121,700 female nurses aged 37-64 at baseline in 1984), Nurses' Health Study II (n=116,671 female nurses aged 27-44 years at baseline in 1991), Health Professionals Follow-up Study (n=51,529 male health professionals aged 40-75 years at baseline in 1986), and Physicians' Health Study (n=22 071 male physicians aged 40-84 years at baseline in 1982). These studies assessed vitamin D through circulating 25-hydroxyvitamin D, dietary and supplemental intake, predicted 25-hydroxyvitamin D, and vitamin D receptor polymorphisms. This review summarizes studies of vitamin D and various endpoints considered in these cohorts, including risk of cardiovascular disease, hypertension, elevated plasma C-peptide, various cancers, bone fractures, and multiple sclerosis. Based on the multiple observed benefits of vitamin D, this article postulates recommendations for vitamin D intake in the US population for reduced incidence of multiple health outcomes.
这一假设，即维生素 D 与多种健康结果呈负相关，已经在哈佛队列研究中进行了研究，包括护士健康研究 I（n=121700 名年龄在 1984 年基线时为 37-64 岁的女性护士）、护士健康研究 II（n=116671 名年龄在 1991 年基线时为 27-44 岁的女性护士）、健康专业人员随访研究（n=51529 名年龄在 1986 年基线时为 40-75 岁的男性健康专业人员）和医师健康研究（n=22071 名年龄在 1982 年基线时为 40-84 岁的男性医生）。这些研究通过循环 25-羟维生素 D、饮食和补充摄入、预测 25-羟维生素 D 和维生素 D 受体多态性来评估维生素 D。这篇综述总结了这些队列研究中维生素 D 和各种终点的研究，包括心血管疾病、高血压、血浆 C 肽升高、各种癌症、骨折和多发性硬化症的风险。基于维生素 D 的多种观察到的益处，本文提出了美国人群维生素 D 摄入量的建议，以降低多种健康结果的发病率。
