Department of Medical Parasitology, New York University School of Medicine, New York, USA.
Am J Trop Med Hyg. 2011 Sep;85(3):414-20. doi: 10.4269/ajtmh.2011.10-0599.
We studied the prevalence of anemia during pregnancy and its relationship with low birth weight (LBW; birth weight < 2,500 g) in Benin. We analyzed 1,508 observations from a randomized controlled trial conducted from 2005 to 2008 showing equivalence on the risk of LBW between two drugs for Intermittent Preventive Treatment of malaria during pregnancy (IPTp). Despite IPTp, helminth prophylaxis, and iron and folic acid supplementations, the proportions of women with severe anemia (hemoglobin [Hb] concentration < 80 g/L) and anemia (Hb < 110 g/L) were high throughout pregnancy: 3.9% and 64.7% during the second and 3.7% and 64.1% during the third trimester, but 2.5% and 39.6% at the onset of labor, respectively. Compared with women without anemia (Hb ≥ 110 g/L) during the third trimester, women with severe anemia (Hb < 80 g/L) were at higher risk of LBW after adjustment for potential confounding factors (prevalence ratio [PR] = 2.8; 95% confidence interval [1.4-5.6]).
我们研究了贝宁孕妇贫血的流行情况及其与低出生体重（LBW；出生体重<2500 克）的关系。我们分析了 2005 年至 2008 年期间进行的一项随机对照试验中的 1508 项观察结果，该试验表明两种用于孕妇间歇性预防治疗疟疾的药物（IPTp）在 LBW 风险方面具有等效性。尽管进行了 IPTp、驱虫预防、铁和叶酸补充，但在整个孕期，严重贫血（血红蛋白[Hb]浓度<80 g/L）和贫血（Hb<110 g/L）的妇女比例仍然很高：在第二个三个月期间分别为 3.9%和 64.7%，在第三个三个月期间分别为 3.7%和 64.1%，但在分娩开始时分别为 2.5%和 39.6%。与第三个三个月无贫血（Hb≥110 g/L）的妇女相比，在调整了潜在混杂因素后，严重贫血（Hb<80 g/L）的妇女 LBW 的风险更高（患病率比[PR] = 2.8；95%置信区间[1.4-5.6]）。
