Koch Michael W, Sánchez Melissa D, Long Sam
Department of Clinical Studies, Internal Medicine Section, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
J Am Anim Hosp Assoc. 2011 Sep-Oct;47(5):e77-85. doi: 10.5326/JAAHA-MS-5551. Epub 2011 Aug 18.
This report describes the clinical, histopathologic, and imaging findings of multifocal oligodendrogliomas from three canine patients. Clinical history varied but included seizure activity and behavior changes. Neurologic examination abnormalities included ataxia, proprioceptive deficits, cranial nerve deficits, and changes in mentation. MRI in one patient revealed multifocal brain lesions; however, the MRI was normal in another one of the patients. Histopathologic evaluation identified multifocal neoplastic infiltrates in all three patients involving the cerebral cortex, brainstem, and spinal cord, with leptomeningeal extension in two of the three patients. All three patients were euthanized due to progression of their neurologic condition and/or complications due to aspiration pneumonia. Oligodendrogliomas should be considered a differential diagnosis for patients with multifocal brain disease.
本报告描述了三只犬多灶性少突胶质细胞瘤的临床、组织病理学和影像学表现。临床病史各不相同，但包括癫痫发作活动和行为改变。神经系统检查异常包括共济失调、本体感觉缺陷、脑神经缺陷和精神状态改变。一名患者的MRI显示多灶性脑病变；然而，另一名患者的MRI正常。组织病理学评估在所有三名患者中均发现多灶性肿瘤浸润，累及大脑皮层、脑干和脊髓，三名患者中有两名出现软脑膜播散。所有三名患者均因神经系统疾病进展和/或吸入性肺炎并发症而实施安乐死。对于患有多灶性脑部疾病的患者，应考虑将少突胶质细胞瘤作为鉴别诊断。
