Department of General Gynecology and Gynecological Urology, University Clinical Center Maribor, Slovenia.
Cancer Biomark. 2010;8(1):29-34. doi: 10.3233/DMA-2011-0817.
The mutant genotype GG of the CYP17A1 gene polymorphism has been linked to higher levels of serum estradiol and thus might be associated with steroid-hormone dependent tumors. We decided to assess an association of CYP17A1 polymorphism with uterine leiomyomas (ULM) and multiple ULM by conducting a meta-analysis and subgroup analysis.
We searched the HuGE Navigator and PubMed databases using the terms "leiomyoma" and "CYP17A1" for articles published by October 1, 2010. Our article in press was added. The selection criteria were (i) cases having ULM, (ii) controls showing no ULM from the same ethnic group, (iii) cases and controls not overlapping. The subgroup analysis included cases having multiple ULM, predisposing black women mostly present with multiple ULM. Pooled risk ratio was calculated using χ
Five papers fulfilled the selection criteria for meta-analysis and two papers for the subgroup analysis. The meta-analysis revealed no association of CYP17A1 polymorphism with all ULM. A high pooled risk ratio for multiple ULM was associated with the presence of mutant genotype GG (RR 3.25).
CYP17A1 polymorphism may be associated with multiple ULM but not with all ULM. The future research might enable us to predict the course of the disease.
CYP17A1 基因多态性的突变基因型 GG 与血清雌二醇水平升高有关，因此可能与类固醇激素依赖性肿瘤有关。我们决定通过进行荟萃分析和亚组分析来评估 CYP17A1 多态性与子宫平滑肌瘤（ULM）和多发性 ULM 的相关性。
我们使用“leiomyoma”和“CYP17A1”术语在 HuGE Navigator 和 PubMed 数据库中进行搜索，以查找截至 2010 年 10 月 1 日发表的文章。我们即将发表的文章也被添加了进去。选择标准是：（i）患有 ULM 的病例；（ii）来自同一种族的没有 ULM 的对照组；（iii）病例和对照组没有重叠。亚组分析包括多发性 ULM 的病例，易患黑色人种的女性大多患有多发性 ULM。使用 χ< formula > ^{2} 统计量计算合并风险比。
五项研究符合荟萃分析的选择标准，两项研究符合亚组分析的选择标准。荟萃分析显示，CYP17A1 多态性与所有 ULM 无关。携带突变基因型 GG 的多发性 ULM 的合并高风险比与突变基因型 GG 的存在相关（RR 3.25）。
CYP17A1 多态性可能与多发性 ULM 相关，但与所有 ULM 无关。未来的研究可能使我们能够预测疾病的进程。
