雌激素受体-α基因多态性与子宫肌瘤风险之间的关联。
The associations between the polymorphisms of the ER-α gene and the risk of uterine leiomyoma (ULM).
作者信息
Feng Yi, Lin Xiaojuan, Zhou Shengtao, Xu Ning, Yi Tao, Zhao Xia
机构信息
Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, No. 20, Section 3, South People's Road, Chengdu, 610041, Sichuan, People's Republic of China.
出版信息
Tumour Biol. 2013 Oct;34(5):3077-82. doi: 10.1007/s13277-013-0874-0. Epub 2013 Jun 9.
The ER-α gene polymorphisms have been reported to be associated with uterine leiomyoma (ULM) risk. The purpose of the present study was to perform a meta-analysis to explore the polymorphisms in the ER-α gene and the risk of ULM. A comprehensive search for relevant articles was conducted in MEDLINE (Ovid), PubMed, Embase, Springer, EBSCO, Web of Science, CNKI, Wanfang, Weipu, and Google Scholar. A total of nine articles were identified. Among the nine articles, 11 cohorts reported the PvuII polymorphism and six reported the XbaI polymorphism. The strength of the relationships between the polymorphisms in ER-α (PvuII and XbaI) and the risk of ULM was assessed by odds ratios (ORs). The studies provided overall OR estimates for PvuII and XbaI, leading to a pooled OR of 1.41 (PP+Pp vs. pp: OR = 1.41, 95 % confidence interval (95 %CI) = 1.02-1.96, P = 0.04), 1.13 (XX+Xx vs. xx: OR = 1.13, 95 %CI = 0.91-1.41, P = 0.25), respectively. The PvuII polymorphism in the ER-α gene may be a risk factor for ULM. Future studies are needed to validate our conclusions.
据报道，雌激素受体α（ER-α）基因多态性与子宫肌瘤（ULM）风险相关。本研究的目的是进行一项荟萃分析，以探讨ER-α基因多态性与ULM风险之间的关系。我们在MEDLINE（Ovid）、PubMed、Embase、Springer、EBSCO、Web of Science、中国知网、万方、维普和谷歌学术等数据库中全面检索了相关文章。共识别出9篇文章。在这9篇文章中，11个队列报告了PvuII多态性，6个队列报告了XbaI多态性。通过比值比（OR）评估ER-α基因多态性（PvuII和XbaI）与ULM风险之间关系的强度。这些研究提供了PvuII和XbaI的总体OR估计值，合并后的OR分别为1.41（PP + Pp vs. pp：OR = 1.41，95%置信区间（95%CI）= 1.02 - 1.96，P = 0.04）和1.13（XX + Xx vs. xx：OR = 1.13，95%CI = 0.91 - 1.41，P = 0.25）。ER-α基因中的PvuII多态性可能是ULM的一个风险因素。需要进一步的研究来验证我们的结论。
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