Kohli Sarvraj Singh, Kohli Virinder Singh
Department of Orthodontics and Dentofacial Orthopaedics, Hitkarini Dental College and Hospital, Dumna Road, Jabalpur 482005, Madhya Pradesh, India.
Indian J Endocrinol Metab. 2011 Jul;15(3):175-81. doi: 10.4103/2230-8210.83401.
Bone remodeling is a cyclic and continuous physiological process, which ensures the conservation and renewal of the bone matrix. Osteosynthesis of the bone matrix is achieved by osteoblasts and coordinated within this complex machinery of bone remodeling with resorption of extracellular bone matrix performed by osteoclasts. The mismatch between the activities of osteoblasts and osteoclasts has immunopathologic implications associated with either a decrease or increase of bone mass mineral density. The balance of the trimolecular control factor complex composed of osteoprotegerin (OPG), RANKL (osteoprotegerin ligand) and RANK maintains physiologic bone remodeling. This trimolecular complex functions as receptors and ligands and belongs to the superfamily of tumor necrosis factor (TNF). This mini review highlights the complex interplay of the RANKL-RANK/OPG axis and their immunopathologic implications in clinical medicine.
骨重塑是一个循环且持续的生理过程，它确保了骨基质的保存与更新。骨基质的骨合成由成骨细胞完成，并在这个复杂的骨重塑机制中与破骨细胞对细胞外骨基质的吸收相协调。成骨细胞与破骨细胞活性之间的不匹配具有与骨矿物质密度降低或增加相关的免疫病理学意义。由骨保护素（OPG）、RANKL（骨保护素配体）和RANK组成的三分子控制因子复合体的平衡维持着生理性骨重塑。这个三分子复合体作为受体和配体发挥作用，属于肿瘤坏死因子（TNF）超家族。这篇小型综述强调了RANKL-RANK/OPG轴的复杂相互作用及其在临床医学中的免疫病理学意义。
