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31 kDa人半乳糖凝集素-7（p53诱导基因1）同型二聚体（一种促凋亡凝集素）的1H、13C和15N主链及侧链化学位移归属

1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 31 kDa human galectin-7 (p53-induced gene 1) homodimer, a pro-apoptotic lectin.

作者信息

Nesmelova Irina V, Berbís Manuel Álvaro, Miller Michelle C, Cañada F Javier, André Sabine, Jiménez-Barbero Jesús, Gabius Hans-Joachim, Mayo Kevin H

机构信息

Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, 6-155 Jackson Hall, 321 Church St., Minneapolis, MN 55455, USA.

出版信息

Biomol NMR Assign. 2012 Oct;6(2):127-9. doi: 10.1007/s12104-011-9339-9. Epub 2011 Sep 7.

DOI:10.1007/s12104-011-9339-9
PMID:21898049
Abstract

Galectins are multifunctional proteins with carbohydrate/protein-binding properties and distinct expression profiles. Homodimeric galectin-7 (p53-induced gene 1) is a potent pro-apoptotic effector with clinical relevance. Here, we report (1)H, (13)C, and (15)N chemical shift assignments for human galectin-7 dimer as determined by using heteronuclear, triple resonance NMR spectroscopy.

摘要

半乳糖凝集素是具有碳水化合物/蛋白质结合特性和独特表达谱的多功能蛋白质。同型二聚体半乳糖凝集素-7（p53诱导基因1）是一种具有临床相关性的强效促凋亡效应物。在此，我们报告了通过使用异核三共振核磁共振光谱法测定的人半乳糖凝集素-7二聚体的（1）H、（13）C和（15）N化学位移归属。

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