疑似托吡酯所致黄斑病变。

Presumed topiramate-induced maculopathy.

作者信息

Beyenburg Stefan, Weyland Christophe, Reuber Markus

机构信息

Service de Neurologie, Centre Hospitalier de Luxembourg, Rue Barblé 4, L-1210 Luxembourg, Luxembourg.

出版信息

Epilepsy Behav. 2009 Mar;14(3):556-9. doi: 10.1016/j.yebeh.2008.12.015. Epub 2009 Jan 14.

DOI:10.1016/j.yebeh.2008.12.015

PMID:19150415

Abstract

The case of a patient who developed decreased vision while taking topiramate (TPM) for symptomatic epilepsy is described. Ophthalmological examination revealed findings suggestive of maculopathy. TPM was discontinued; however, vision failed to improve significantly over 6 months of follow-up. We hypothesize that the patient's maculopathy was induced by TPM. TPM, like vigabatrin, may exert retinal toxicity causing persistent visual impairment.

摘要

描述了一名有症状性癫痫患者在服用托吡酯（TPM）期间出现视力下降的病例。眼科检查发现提示存在黄斑病变。停用了TPM；然而，在6个月的随访中视力未能显著改善。我们推测该患者的黄斑病变是由TPM引起的。TPM与氨己烯酸一样，可能会产生视网膜毒性，导致持续性视力损害。