通过迈克尔加成-RCM 策略实现功能性 calyciphylline A 型骨架的便捷途径。

Expedient Route to the functionalized calyciphylline A-type skeleton via a Michael addition-RCM strategy.

机构信息

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

出版信息

Org Lett. 2011 Oct 7;13(19):5132-5. doi: 10.1021/ol202000w. Epub 2011 Sep 7.

DOI:10.1021/ol202000w

Abstract

An efficient, robust, and scalable strategy to access the functionalized core of calyciphylline A-type alkaloids has been developed starting from commercially available 3-methylanisole. Key features of this approach are an intramolecular Michael addition/allylation sequence and a ring-closing metathesis step.

摘要

现已开发出一种从商业可得的 3-甲基茴香醚出发，获取具有官能化核心的贝壳杉烷型生物碱的有效、稳健且可扩展的策略。此方法的关键特征是分子内迈克尔加成/烯丙基化序列和闭环复分解步骤。