合成美登素类生物碱五环核心的策略。
Synthetic Strategy toward the Pentacyclic Core of Melodinus Alkaloids.
机构信息
Academy of Scientific and Innovative Research (AcSIR) , New Delhi, India.
出版信息
J Org Chem. 2018 Feb 16;83(4):2244-2249. doi: 10.1021/acs.joc.7b03138. Epub 2018 Jan 26.
PMID:29338221
Abstract
The three-component Povarov reaction is efficiently utilized for construction of the pentacyclic framework of complex Melodinus alkaloids, which is amenable to expansion to other complex natural products. The key steps were Povarov reaction, one-pot reductive cyclization, and ring-closing metathesis (RCM) reaction.
摘要
该三组分 Povarov 反应高效地构建了复杂的醉茄生物碱的五环骨架，这一方法可扩展至其它复杂天然产物的合成。关键步骤为 Povarov 反应、一锅还原环化和关环复分解（RCM）反应。
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