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血清利奈唑胺浓度与血小板减少症发生之间的相关性。

Correlation between serum linezolid concentration and the development of thrombocytopenia.

作者信息

Hiraki Yoichi, Tsuji Yasuhiro, Hiraike Mikako, Misumi Nobuhiro, Matsumoto Kana, Morita Kunihiko, Kamimura Hidetoshi, Karube Yoshiharu

机构信息

Department of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto, Kumamoto, Japan.

出版信息

Scand J Infect Dis. 2012 Jan;44(1):60-4. doi: 10.3109/00365548.2011.608712. Epub 2011 Sep 7.

DOI:10.3109/00365548.2011.608712
PMID:21899392
Abstract

We evaluated the possible association between trough linezolid (LZD) concentrations and platelet counts using a dose-response curve with a logit model equation. We demonstrated that trough LZD concentrations correlated with platelet counts. A significant decrease in platelet count was observed in patients with trough LZD concentrations higher than 22.1 μg/ml.

摘要

我们使用带有逻辑模型方程的剂量反应曲线评估了利奈唑胺（LZD）谷浓度与血小板计数之间的可能关联。我们证明了LZD谷浓度与血小板计数相关。在LZD谷浓度高于22.1μg/ml的患者中观察到血小板计数显著下降。

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Correlation between serum linezolid concentration and the development of thrombocytopenia.血清利奈唑胺浓度与血小板减少症发生之间的相关性。
Scand J Infect Dis. 2012 Jan;44(1):60-4. doi: 10.3109/00365548.2011.608712. Epub 2011 Sep 7.
2
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High plasma linezolid concentration and impaired renal function affect development of linezolid-induced thrombocytopenia.高血浆利奈唑胺浓度和肾功能受损影响利奈唑胺诱导的血小板减少症的发生。
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Dosage Strategy of Linezolid According to the Trough Concentration Target and Renal Function in Chinese Critically Ill Patients.中国重症患者中基于谷浓度目标和肾功能的利奈唑胺给药策略
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