Department of Exercise Physiology, Ardabil Branch, Islamic Azad University, Ardabil, Iran.
J Pharm Pharmacol. 2011 Oct;63(10):1290-4. doi: 10.1111/j.2042-7158.2011.01314.x. Epub 2011 Aug 1.
This study was conducted to assess the effects of chronic daily methylsulfonylmethane (MSM) supplementation on known markers of oxidative stress following acute bouts of exercise in untrained healthy young men.
Eighteen untrained men volunteered for this study. Participants were randomized in a double-blind placebo-controlled fashion into two groups: MSM (n = 9) and placebo (n = 9). The participants took supplementation or placebo daily for 10 days before running. Participants ran 14 km. The MSM supplementation was prepared in water at 50 mg/kg body weight. The placebo group received water. Serum malondialdehyde (MDA), protein carbonyl (PC) and plasma oxidized glutathione (GSSG) were measured as markers of oxidative stress. The plasma-reduced glutathione (GSH) level and the GSH/GSSG ratio were determined as markers of plasma antioxidant capacity.
Acute exercise led to elevated levels of serum MDA, PC and plasma GSSG. MSM supplementation maintained PC, MDA and GSSG at lower levels after exercise than the placebo. The plasma level of GSH and the ratio of GSH/GSSG were significantly higher in the MSM supplemented group.
These results suggest that chronic daily oral supplementation of MSM has alleviating effects on known markers of oxidative stress following acute bouts of exercise in healthy young men.
本研究旨在评估慢性每日补充甲基磺酰甲烷（MSM）对未经训练的健康年轻男性急性运动后已知氧化应激标志物的影响。
18 名未经训练的男性自愿参加了这项研究。参与者以双盲安慰剂对照的方式随机分为两组：MSM（n = 9）和安慰剂（n = 9）。参与者在跑步前每天服用补充剂或安慰剂 10 天。参与者跑 14 公里。MSM 补充剂在水中以 50mg/kg 体重的浓度制备。安慰剂组则服用水。血清丙二醛（MDA）、蛋白羰基（PC）和血浆氧化型谷胱甘肽（GSSG）作为氧化应激的标志物进行测量。血浆还原型谷胱甘肽（GSH）水平和 GSH/GSSG 比值作为血浆抗氧化能力的标志物进行测定。
急性运动导致血清 MDA、PC 和血浆 GSSG 水平升高。与安慰剂相比，MSM 补充剂可使运动后 PC、MDA 和 GSSG 维持在较低水平。补充 MSM 的血浆 GSH 水平和 GSH/GSSG 比值显著升高。
这些结果表明，慢性每日口服 MSM 补充剂可减轻健康年轻男性急性运动后已知的氧化应激标志物。
