Department of Physiology & Pharmacology, Campus M. Unamuno, University of Salamanca, E-37007 Salamanca, Spain.
Toxicology. 2010 Nov 28;278(1):101-11. doi: 10.1016/j.tox.2009.10.015. Epub 2009 Oct 24.
The efficacy of long-term intake of a novel functional food supplement Funciona™ containing vitamins and juiced fruits was evaluated in order to assess the net effect of physical activity and antioxidant potentials in healthy older adult population. The long-term (2 years) and large-scale (400 older adult subjects) interventional study was based on both moderate-intensity exercise practice and concurrent supplementation. Sustained exercise-induced oxidative stress as reflected in significantly increased blood thiobarbituric acid-reactive substances (TBARS) (+15%), protein carbonyl groups (PC) (+18%) and oxidized glutathione (GSSG) (+112%) concentrations, and leukocyte 8-OHdG contents (23%). Exercise decreased the reduced/oxidized glutathione (GSH/GSSG) molar ratio (-43%) and plasma vitamin C levels (-22%). Supplementation with Funciona™ was significant in preventing oxidative damage to lipid, protein and DNA, and normalizing blood GSSG, GSH/GSSG and vitamin C levels. Thus daily intake of the antioxidant functional beverage counteracts the exercise-induced oxidative stress in free-living older subjects, and might be necessary to restore impaired antioxidant balance due long-term regular exercise.
为了评估身体活动和抗氧化潜能对健康老年人群的净效应，评估了长期（2 年）、大规模（400 名老年受试者）干预研究中新型功能性食品补充剂 Funciona™（含维生素和鲜榨果汁）的长期摄入效果。该补充剂基于适度运动实践和同时进行的补充。持续的运动诱导的氧化应激反映在血液硫代巴比妥酸反应物质（TBARS）（增加 15%）、蛋白质羰基（PC）（增加 18%）和氧化型谷胱甘肽（GSSG）（增加 112%）浓度以及白细胞 8-OHdG 含量（增加 23%）显著增加。运动降低了还原/氧化型谷胱甘肽（GSH/GSSG）摩尔比（减少 43%）和血浆维生素 C 水平（减少 22%）。Funciona™ 的补充在预防脂质、蛋白质和 DNA 的氧化损伤以及使血液 GSSG、GSH/GSSG 和维生素 C 水平正常化方面具有显著效果。因此，每天摄入抗氧化功能性饮料可以抵抗自由生活的老年受试者中的运动诱导的氧化应激，并且可能由于长期定期运动而导致抗氧化平衡受损，因此补充 Funciona™ 是必要的。
