Yamamoto K, Shibata T, Saji H, Kubo S, Aoki E, Fujita T, Yonekura Y, Konishi J, Yokoyama A
Department of Radiology and Nuclear Medicine, Kyoto University School of Medicine, Japan.
J Nucl Med. 1990 Jun;31(6):1015-9.
The pancreatic affinity of iodine-123-labeled HIPDM (N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propane diamine) ([123I]HIPDM) was studied in 18 cases (5 normal volunteers, 7 cases with pancreas cancer, and 6 with chronic pancreatitis). In the normal cases, the pancreas was visualized in the planar images as early as 3 hr, and again at 20 hr postinjection. Single-photon emission computed tomography (SPECT) performed following 3-hr planar scintigraphy, provided excellent pancreas images without an overlap of activity in the liver or spleen. The mean pancreas-to-liver (P/L) ratio was 1.26 +/- 0.22 in normal controls. With the exception of one case of massive calcification in the pancreas, the entire pancreas could be observed in the cases with chronic pancreatitis, but the P/L ratio was 0.74 +/- 0.15, significantly lower than that of normal cases. Defective areas of the distal portion of the pancreas were clearly seen in those with cancer of the pancreas. The results of our study indicate that [123I] HIPDM may have clinical potential as a human pancreas imaging agent.
对18例患者（5名正常志愿者、7例胰腺癌患者和6例慢性胰腺炎患者）进行了碘-123标记的HIPDM（N，N，N'-三甲基-N'-（2-羟基-3-甲基-5-碘苄基）-1，3-丙二胺）（[123I]HIPDM）的胰腺亲和力研究。在正常病例中，胰腺在平面图像中最早在注射后3小时显影，20小时时再次显影。在3小时平面闪烁扫描后进行的单光子发射计算机断层扫描（SPECT）提供了出色的胰腺图像，肝脏或脾脏中没有放射性重叠。正常对照组的平均胰腺与肝脏（P/L）比值为1.26±0.22。除1例胰腺大量钙化外，慢性胰腺炎患者的整个胰腺均可观察到，但P/L比值为0.74±0.15，明显低于正常病例。胰腺癌患者胰腺远端的缺损区域清晰可见。我们的研究结果表明，[123I]HIPDM作为一种人体胰腺成像剂可能具有临床应用潜力。
