Moretti J L, Kung H F, Cesaro P, Blau M, Defer G, Holman L, Vigneron N, Rapin J R
Département of Neurosciences, Creteil, France.
Nucl Med Commun. 1987 Jul;8(7):597-602.
Early and late brain distribution of iodine-labelled N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine (HIPDM) and iodine labelled N-isopropyl-p-iodoamphetamine (IMP) were compared in rat and one human patient with a recent stroke in the right middle cerebral artery area. In rat, an important 'redistribution' of cerebral activity was observed in various areas of the brain, mainly white matter, whereas no such observation was made with HIPDM. In the patient, the right area was hypoactive during the early SPECT with IMP and HIPDM, and redistribution was observed in the late SPECT only with IMP. We suggest that while HIPDM appears to reflect regional cerebral perfusion, IMP distribution is dependent upon metabolic brain activity.
在大鼠和一名近期右侧大脑中动脉区域中风的人类患者中，比较了碘标记的N,N,N'-三甲基-N'-(2-羟基-3-甲基-5-碘苄基)-1,3-丙二胺（HIPDM）和碘标记的N-异丙基-p-碘安非他明（IMP）的早期和晚期脑部分布。在大鼠中，在大脑的各个区域，主要是白质中观察到了脑活动的重要“再分布”，而HIPDM未观察到这种情况。在患者中，早期单光子发射计算机断层扫描（SPECT）时，IMP和HIPDM显示右侧区域活性降低，仅在晚期SPECT中观察到IMP的再分布。我们认为，虽然HIPDM似乎反映了局部脑灌注，但IMP的分布取决于脑代谢活动。
