Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA.
Nutr J. 2011 Sep 7;10:90. doi: 10.1186/1475-2891-10-90.
While exercise acts to combat inflammation and aging, the ability to exercise may itself be compromised by inflammation and inflammation's impact on muscle recovery and joint inflammation. A number of nutritional supplements have been shown to reduce inflammation and improve recovery. The purpose of the current investigation was to examine the effect of a multi-nutrient supplement containing branched chain amino acids, taurine, anti-inflammatory plant extracts, and B vitamins on inflammatory status, endothelial function, physical function, and mood in middle-aged individuals.
Thirty-one healthy and active men (N = 16, mean age 56 ± 6.0 yrs) and women (N = 15, mean age = 52 ± 7.5 yrs) participated in this investigation. Subjects completed one 28 day cycle of placebo supplementation and one 28 day cycle of multi-nutrient supplementation (separated by a one week washout period) in a balanced, randomized, double-blind, cross-over design. Subjects completed weekly perceptual logs (PROMIS-57, KOOS) and pre- and post- testing around the supplementation period. Testing consisted of brachial artery flow mediated dilation (FMD), blood measures, and physical performance on vertical jump, handgrip strength, and balance (dispersion from center of pressure). Significance for the investigation was p ≤ 0.05.
IL-6 significantly decreased in both men (from 1.2 ± 0.2 to 0.7 ± 0.4 pg·mL(-1)) and women (from 1.16 ± 0.04 to 0.7 ± 0.4 pg·mL(-1)). Perceived energy also improved for both men (placebo: 1.8 ± 0.7; supplement: 3.7 ± 0.8 AUC) and women (placebo: 1.2 ± 0.7; supplement: 2.8 ± 0.8 AUC). Alpha-1-antichymotrypsin (from 108.9 ± 38.6 to 55.5 ± 22.2 ug·mL(-1)), Creatine Kinase (from 96 ± 34 to 67 ± 23 IU·L(-1)), general pain, and joint pain decreased in men only, while anxiety and balance (from 0.52 ± 0.13 to 0.45 ± 0.12 cm) improved in women only. Men showed increased performance in vertical jump power (from 2642 ± 244 to 3134 ± 282 W) and grip strength (from 42.1 ± 5.9 to 48.5 ± 4.9 kg).
A multi-nutrient supplement is effective in improving inflammatory status in both men and women, markers of pain, joint pain, strength, and power in men only, and both anxiety and balance (a risk factor for hip fracture) in women. Therefore, a multi-nutrient supplement may help middle-aged individuals to prolong physical function and maintain a healthy, active lifestyle.
运动可以对抗炎症和衰老，但运动能力本身可能会因炎症以及炎症对肌肉恢复和关节炎症的影响而受损。一些营养补充剂已被证明可以减轻炎症并促进恢复。本研究的目的是检查含有支链氨基酸、牛磺酸、抗炎植物提取物和 B 族维生素的多种营养素补充剂对中年人群的炎症状态、内皮功能、身体功能和情绪的影响。
31 名健康活跃的男性（N=16，平均年龄 56±6.0 岁）和女性（N=15，平均年龄 52±7.5 岁）参与了这项研究。受试者以平衡、随机、双盲、交叉的方式完成了为期 28 天的安慰剂补充和为期 28 天的多种营养素补充周期（间隔一周洗脱期）。受试者每周完成一次感知日志（PROMIS-57、KOOS），并在补充期前后进行测试。测试包括肱动脉血流介导的扩张（FMD）、血液测量以及垂直跳跃、握力和平衡（从中心压力分散）的身体表现。研究的显著性水平为 p≤0.05。
男性的白细胞介素 6（IL-6）水平显著下降（从 1.2±0.2 降至 0.7±0.4 pg·mL(-1)），女性的白细胞介素 6 水平也显著下降（从 1.16±0.04 降至 0.7±0.4 pg·mL(-1)）。男性的感知能量也有所改善（安慰剂：1.8±0.7；补充剂：3.7±0.8 AUC），女性的感知能量也有所改善（安慰剂：1.2±0.7；补充剂：2.8±0.8 AUC）。男性的α-1-抗胰蛋白酶（从 108.9±38.6 降至 55.5±22.2 ug·mL(-1)）、肌酸激酶（从 96±34 降至 67±23 IU·L(-1)）、一般性疼痛和关节疼痛均有所下降，而女性的焦虑和平衡（从 0.52±0.13 降至 0.45±0.12 cm）则有所改善。男性的垂直跳跃力（从 2642±244 增加到 3134±282 W）和握力（从 42.1±5.9 增加到 48.5±4.9 kg）均有所提高。
多种营养素补充剂可有效改善男性和女性的炎症状态、疼痛标志物、男性的关节疼痛、力量和力量，以及女性的焦虑和平衡（髋关节骨折的一个风险因素）。因此，多种营养素补充剂可能有助于中年人群延长身体功能并保持健康、活跃的生活方式。
