Fox Christopher P, Shannon-Lowe Claire, Rowe Martin
University of Birmingham College of Medical and Dental Sciences, School of Cancer Sciences, Edgbaston, Birmingham, B15 2TT, UK.
Herpesviridae. 2011 Sep 7;2:8. doi: 10.1186/2042-4280-2-8.
Epstein-Barr virus (EBV) is a highly successful herpesvirus, colonizing more than 90% of the adult human population worldwide, although it is also associated with various malignant diseases. Primary infection is usually clinically silent, and subsequent establishment of latency in the memory B lymphocyte compartment allows persistence of the virus in the infected host for life. EBV is so markedly B-lymphotropic when exposed to human lymphocytes in vitro that the association of EBV with rare but distinct types of T and NK cell lymphoproliferations was quite unexpected. Whilst relatively rare, these EBV-associated T and NK lymphoproliferations can be therapeutically challenging and prognosis for the majority of patients is dismal. In this review, we summarize the current knowledge on the role of EBV in the pathogenesis of these tumours, and the implications for treatment.
爱泼斯坦-巴尔病毒（EBV）是一种非常成功的疱疹病毒，全球超过90%的成年人口都携带该病毒，尽管它也与多种恶性疾病有关。初次感染通常在临床上没有症状，随后在记忆B淋巴细胞区室中建立潜伏状态，使得病毒能够在受感染宿主中终生持续存在。当在体外与人淋巴细胞接触时，EBV对B淋巴细胞具有显著的嗜性，因此EBV与罕见但独特类型的T细胞和自然杀伤（NK）细胞淋巴增殖性疾病的关联相当出乎意料。虽然这些EBV相关的T细胞和NK细胞淋巴增殖性疾病相对罕见，但治疗起来颇具挑战性，大多数患者的预后很差。在这篇综述中，我们总结了目前关于EBV在这些肿瘤发病机制中的作用的知识，以及对治疗的影响。
