Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Curr Opin Immunol. 2011 Dec;23(6):702-6. doi: 10.1016/j.coi.2011.08.007. Epub 2011 Sep 6.
Th17 cells have been shown to be strong inducers of tissue inflammation and autoimmune diseases. However, not all Th17 cells are pathogenic and increasing data suggest that Th17 cells may come in different flavors. Thus, Th17 cells cannot be described using a narrow schematic, but instead Th17 cells comprise a wide spectrum with a range of effector phenotypes. Here, we review the key factors that generate such diversity, as well as the cytokines and transcription factors that are differentially expressed in pathogenic and nonpathogenic Th17 cells. This new knowledge can be used to identify molecules that make Th17 cells pathogenic and determine how these cells could be targeted to suppress autoimmune diseases.
Th17 细胞已被证明是组织炎症和自身免疫性疾病的强烈诱导剂。然而，并非所有 Th17 细胞都是致病性的，越来越多的数据表明 Th17 细胞可能具有不同的表型。因此，不能用狭隘的模式图来描述 Th17 细胞，而应该将 Th17 细胞视为一个具有广泛效应表型范围的谱。在这里，我们综述了产生这种多样性的关键因素，以及在致病性和非致病性 Th17 细胞中差异表达的细胞因子和转录因子。这些新知识可用于鉴定使 Th17 细胞具有致病性的分子，并确定如何靶向这些细胞来抑制自身免疫性疾病。
