Department of Ecology and Evolution, Committee on Genetics, Genomics and Systems Biology, Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois 60637, USA.
Genetics. 2011 Nov;189(3):1121-6. doi: 10.1534/genetics.111.133637. Epub 2011 Sep 6.
We tested whether functionally important sites in bacterial, yeast, and animal promoters are more conserved than their neighbors. We found that substitutions are predominantly seen in less important sites and that those that occurred tended to have less impact on gene expression than possible alternatives. These results suggest that purifying selection operates on promoter sequences.
我们测试了细菌、酵母和动物启动子中功能重要的位点是否比其相邻区域更保守。我们发现，取代主要发生在不太重要的位点，而且发生的取代对基因表达的影响往往小于可能的替代物。这些结果表明，启动子序列受到了净化选择的作用。
