Izumi Y, Ishii K, Akiba K, Hayashi T
Yamagata University School of Medicine, Department of Pediatrics, Japan.
Med Hypotheses. 1990 May;32(1):77-80. doi: 10.1016/0306-9877(90)90073-n.
Febrile convulsions are generally thought to be induced by metabolic changes during the rise-phase of body temperature. The mechanism by which convulsions are induced, however, is not fully elucidated. In this article, we propose a new hypothesis about the induction mechanism of febrile convulsions that takes into account the hypozincemia during fever. This hypozincemia activates the NMDA receptor, one of the glutamate family of receptors, which may play an important role in the induction of epileptic discharge.
热性惊厥通常被认为是由体温上升阶段的代谢变化所诱发。然而，惊厥的诱发机制尚未完全阐明。在本文中，我们提出了一个关于热性惊厥诱发机制的新假说，该假说考虑了发热期间的低锌血症。这种低锌血症会激活NMDA受体，它是谷氨酸受体家族中的一员，可能在癫痫放电的诱发中起重要作用。
