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对胃肠动力障碍理解的新见解。

New insights into the understanding of gastrointestinal dysmotility.

作者信息

Ohlsson Bodil, Janciauskiene Sabina

机构信息

Department of Clinical Sciences, Gastroenterology Division, Entrance 46, 2nd floor, University Hospital Malmö, Lund University, 20502 Malmö, Sweden.

出版信息

Drug Target Insights. 2007;2:229-37. Epub 2007 Sep 25.

PMID:21901077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3155233/
Abstract

Our understanding of the physiology of digestion, absorption, secretion, and motility in the gastrointestinal tract has improved immensely. Today it is well established that the gross functions of the gastrointestinal tract depend on the coordination between the muscles, nerves and hormones. The enteric nervous system (ENS) is involved in most of the physiological and pathophysiological processes in the gastrointestinal tract. Therefore, clinical and experimental studies on the ENS provide the basis for a better understanding of the mechanisms involved in gastrointestinal disorders and promote the development of therapeutic options. This review outlines some of the current views on the role of the ENS and its related hormones in gastrointestinal motility.

摘要

我们对胃肠道消化、吸收、分泌和蠕动生理过程的理解有了极大的提高。如今,人们已经清楚地认识到胃肠道的总体功能取决于肌肉、神经和激素之间的协调。肠神经系统(ENS)参与了胃肠道的大多数生理和病理生理过程。因此,关于肠神经系统的临床和实验研究为更好地理解胃肠道疾病的发病机制提供了基础,并促进了治疗方案的发展。这篇综述概述了目前关于肠神经系统及其相关激素在胃肠动力中作用的一些观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9157/3155233/d22b0c58bb2f/dti-2-2007-229f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9157/3155233/d22b0c58bb2f/dti-2-2007-229f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9157/3155233/d22b0c58bb2f/dti-2-2007-229f1.jpg

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本文引用的文献

1
Relation among plasma ghrelin level, gastric emptying, and psychologic condition in patients with functional dyspepsia.功能性消化不良患者血浆胃饥饿素水平、胃排空及心理状态之间的关系。
J Clin Gastroenterol. 2007 May-Jun;41(5):477-83. doi: 10.1097/01.mcg.0000225614.94470.47.
2
Obestatin--a ghrelin-associated peptide that does not hold its promise to suppress food intake and motility.肥胖抑制素——一种与胃饥饿素相关的肽,但其在抑制食物摄入和胃肠蠕动方面并未达到预期效果。
Neurogastroenterol Motil. 2007 Mar;19(3):161-5. doi: 10.1111/j.1365-2982.2007.00916.x.
3
Chronic intestinal pseudo-obstruction due to buserelin-induced formation of anti-GnRH antibodies.
布舍瑞林诱导抗促性腺激素释放激素抗体形成导致的慢性肠道假性梗阻
Gastroenterology. 2007 Jan;132(1):45-51. doi: 10.1053/j.gastro.2006.10.036.
4
Serotonin and its role in colonic function and in gastrointestinal disorders.血清素及其在结肠功能和胃肠道疾病中的作用。
Dis Colon Rectum. 2007 Mar;50(3):376-88. doi: 10.1007/s10350-006-0763-3.
5
5-HT in the enteric nervous system: gut function and neuropharmacology.肠神经系统中的5-羟色胺:肠道功能与神经药理学
Trends Neurosci. 2007 Jan;30(1):9-13. doi: 10.1016/j.tins.2006.11.002. Epub 2006 Nov 28.
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A case report on a patient suffering from recurrent vomiting episodes, whose condition improved markedly during pregnancy and breast feeding.
BMC Gastroenterol. 2006 Oct 21;6:28. doi: 10.1186/1471-230X-6-28.
7
alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis.α-1抗胰蛋白酶抑制半胱天冬酶-3的活性,从而防止肺内皮细胞凋亡。
Am J Pathol. 2006 Oct;169(4):1155-66. doi: 10.2353/ajpath.2006.060058.
8
Sustained versus transient ERK1/2 signaling underlies the anti- and proapoptotic effects of oxidative stress in human RPE cells.持续与瞬时的细胞外信号调节激酶1/2(ERK1/2)信号传导是氧化应激对人视网膜色素上皮(RPE)细胞产生抗凋亡与促凋亡作用的基础。
Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4614-23. doi: 10.1167/iovs.06-0297.
9
Inhibition of arachidonic acid release by cytosolic phospholipase A2 is involved in the antiapoptotic effect of FK506 and cyclosporin a on astrocytes exposed to simulated ischemia in vitro.胞质型磷脂酶A2对花生四烯酸释放的抑制作用参与了FK506和环孢素A在体外对暴露于模拟缺血环境中的星形胶质细胞的抗凋亡作用。
J Pharmacol Sci. 2006 Sep;102(1):77-87.
10
Novel mutations of RET gene in Korean patients with sporadic Hirschsprung's disease.
J Pediatr Surg. 2006 Jul;41(7):1250-4. doi: 10.1016/j.jpedsurg.2006.03.051.