Kantonsspital St. Gallen, Institute of Legal Medicine St. Gallen, St. Gallen, Switzerland.
Int J Legal Med. 2012 Jan;126(1):157-60. doi: 10.1007/s00414-011-0615-0. Epub 2011 Sep 8.
In forensic examination it is a standard to take vaginal swabs from victims of sexual assault for further molecular genetic analysis. Laboratories then are usually confronted with mixtures of lots of female and only a small amount of male DNA. Nowadays it is possible to work with specific Y chromosomal markers after DNA extraction by differential lysis. The determined ratio of autosomal DNA and Y chromosomal DNA can be used to identify the possibility of generating a male profile in these samples.
在法医检查中,从性侵犯受害者身上采集阴道拭子进行进一步的分子遗传学分析是一项标准。实验室通常会遇到大量女性 DNA 和少量男性 DNA 的混合物。如今,通过 DNA 提取后的差异裂解,可以使用特定的 Y 染色体标记进行工作。确定常染色体 DNA 和 Y 染色体 DNA 的比例可用于确定在这些样本中生成男性图谱的可能性。