Department of Biochemistry and Molecular Biology, and Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Org Lett. 2011 Oct 7;13(19):5012-5. doi: 10.1021/ol201773f. Epub 2011 Sep 8.
Triazine-bridged bicyclic peptoids as conformationally constrained peptidomimetics are described. Bicyclic peptoids composed of 6-12 peptoid residues (m, n = 3-6) were synthesized in excellent yields using a highly efficient solid-phase synthetic route.
本文描述了作为构象约束性肽类似物的三嗪桥联双环缩肽。采用高效固相合成路线，以优异的收率合成了由 6-12 个缩肽残基（m，n = 3-6）组成的双环缩肽。
