• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Biosynthesis of cholesterol and other sterols.

作者信息

Nes W David

机构信息

Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, USA.

出版信息

Chem Rev. 2011 Oct 12;111(10):6423-51. doi: 10.1021/cr200021m. Epub 2011 Sep 8.

DOI:10.1021/cr200021m
PMID:21902244
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3191736/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/c90f9c43feeb/cr-2011-00021m_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/c20ac87509fb/cr-2011-00021m_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/c4c5e7dddf65/cr-2011-00021m_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/21ad8a6d36b7/cr-2011-00021m_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/584dfa284eb0/cr-2011-00021m_0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/7a2ea1ac90fb/cr-2011-00021m_0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/70a6444d4d32/cr-2011-00021m_0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/6c7e0e111400/cr-2011-00021m_0015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/6741238c9d4b/cr-2011-00021m_0016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/7d3a3f080678/cr-2011-00021m_0017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/c51bfe6ca133/cr-2011-00021m_0018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/642f972447f2/cr-2011-00021m_0019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/6eb6d1dd9048/cr-2011-00021m_0020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/a7eb670c4185/cr-2011-00021m_0021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/9fd1df509c8d/cr-2011-00021m_0022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/ff91710b0a3b/cr-2011-00021m_0023.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/398bd25c305a/cr-2011-00021m_0024.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/2d561aa67b48/cr-2011-00021m_0025.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/268adf272d43/cr-2011-00021m_0026.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/73219d2481b6/cr-2011-00021m_0027.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/f3e479ef24eb/cr-2011-00021m_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/e635b1d37e66/cr-2011-00021m_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/21472c5a4597/cr-2011-00021m_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/c90f9c43feeb/cr-2011-00021m_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/c20ac87509fb/cr-2011-00021m_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/c4c5e7dddf65/cr-2011-00021m_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/21ad8a6d36b7/cr-2011-00021m_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/584dfa284eb0/cr-2011-00021m_0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/7a2ea1ac90fb/cr-2011-00021m_0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/70a6444d4d32/cr-2011-00021m_0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/6c7e0e111400/cr-2011-00021m_0015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/6741238c9d4b/cr-2011-00021m_0016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/7d3a3f080678/cr-2011-00021m_0017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/c51bfe6ca133/cr-2011-00021m_0018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/642f972447f2/cr-2011-00021m_0019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/6eb6d1dd9048/cr-2011-00021m_0020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/a7eb670c4185/cr-2011-00021m_0021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/9fd1df509c8d/cr-2011-00021m_0022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/ff91710b0a3b/cr-2011-00021m_0023.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/398bd25c305a/cr-2011-00021m_0024.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/2d561aa67b48/cr-2011-00021m_0025.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/268adf272d43/cr-2011-00021m_0026.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/73219d2481b6/cr-2011-00021m_0027.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/f3e479ef24eb/cr-2011-00021m_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/e635b1d37e66/cr-2011-00021m_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/21472c5a4597/cr-2011-00021m_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db6/3191736/c90f9c43feeb/cr-2011-00021m_0004.jpg

相似文献

1
Biosynthesis of cholesterol and other sterols.胆固醇及其他甾醇的生物合成。
Chem Rev. 2011 Oct 12;111(10):6423-51. doi: 10.1021/cr200021m. Epub 2011 Sep 8.
2
Role of 8(14) monoene sterols in cholesterol biosynthesis.8(14)单烯甾醇在胆固醇生物合成中的作用。
Life Sci II. 1970 Nov 8;9(21):1201-5. doi: 10.1016/0024-3205(70)90231-6.
3
Investigations of the capacity of synthesizing 3beta-sterols in Mollusca. XIII. Biosynthesis and composition of sterols in some bivalves (Anisomyaria).软体动物合成3β-甾醇能力的研究。第十三部分。一些双壳贝类(不等肌蛤类)中甾醇的生物合成与组成
Comp Biochem Physiol B. 1975 Apr 15;50(4):499-504. doi: 10.1016/0305-0491(75)90078-4.
4
The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection into developing brain of (2- 14 C)mevalonic.脑组织中胆固醇和其他固醇的生物合成。向发育中大脑脑内注射(2-¹⁴C)甲羟戊酸后,作为时间函数在亚细胞组分中的分布。
J Neurochem. 1972 Jan;19(1):101-7. doi: 10.1111/j.1471-4159.1972.tb01258.x.
5
The biosynthesis of cholesterol and other sterols by brain tissue. I. Subcellular biosynthesis in vitro.脑组织中胆固醇及其他固醇的生物合成。I. 体外亚细胞生物合成
Lipids. 1971 Mar;6(3):154-61. doi: 10.1007/BF02533029.
6
The biosynthesis of squalene, lanosterol, and cholesterol by minced human placenta.人胎盘匀浆合成角鲨烯、羊毛甾醇和胆固醇的过程
Biochemistry. 1966 Jun;5(6):1805-14. doi: 10.1021/bi00870a005.
7
Specificity of enzymes of sterol biosynthesis.固醇生物合成中酶的特异性。
Harvey Lect. 1971;65:127-56.
8
[Plant sterols biosynthesis].[植物甾醇生物合成]
Postepy Biochem. 1972;18(2):257-72.
9
Formation of methyl sterols in brain cholesterol biosynthesis. Sterol formation in vitro in actively myelinating rat brain.脑胆固醇生物合成中甲基甾醇的形成。在活跃髓鞘形成的大鼠脑中进行体外甾醇形成。
J Biol Chem. 1972 Jun 10;247(11):3471-5.
10
The biosynthesis of cholesterol and other sterols by brain tissue: distribution in subcellular fractions as a function of time after injection of (2-14C) mevalonic acid, sodium (2-14C)acetate and (U-14C) glucose into 15-day old rats.脑组织中胆固醇及其他固醇的生物合成:在向15日龄大鼠注射(2-¹⁴C)甲羟戊酸、(2-¹⁴C)乙酸钠和(U-¹⁴C)葡萄糖后,作为时间函数的亚细胞组分分布情况。
J Neurochem. 1975 Jan;24(1):117-21. doi: 10.1111/j.1471-4159.1975.tb07636.x.

引用本文的文献

1
Astrocyte-Neuron Metabolic Synergies in Neurological Homeostasis and Disease.神经稳态与疾病中的星形胶质细胞-神经元代谢协同作用
Neurochem Res. 2025 Sep 9;50(5):293. doi: 10.1007/s11064-025-04548-y.
2
Osteogenic Potential of Simvastatin and Fluvastatin in an Organotypic Bone Model.辛伐他汀和氟伐他汀在器官型骨模型中的成骨潜力
Pharmaceuticals (Basel). 2025 Jun 21;18(7):939. doi: 10.3390/ph18070939.
3
Mechanisms of osteopontin-stabilized amorphous calcium phosphate calcification in benign and pre-malignant breast disease.骨桥蛋白稳定的无定形磷酸钙在良性和癌前乳腺疾病中钙化的机制

本文引用的文献

1
Sex hormones of the aquatic fungusAchlya.水生真菌绵霉的性激素。
Lipids. 1978 Oct;13(10):716-22. doi: 10.1007/BF02533751.
2
Effect of substrate features and mutagenesis of active site tyrosine residues on the reaction course catalysed by Trypanosoma brucei sterol C-24-methyltransferase.底物特征和活性位点酪氨酸残基突变对布氏锥虫固醇 C-24-甲基转移酶催化反应过程的影响。
Biochem J. 2011 Nov 1;439(3):413-22. doi: 10.1042/BJ20110865.
3
Dissecting the sterol C-4 demethylation process in higher plants. From structures and genes to catalytic mechanism.
Sci Rep. 2025 Jul 4;15(1):23849. doi: 10.1038/s41598-025-08903-5.
4
Identifying and quantifying membrane interactions of the protein human cis-prenyltransferase.鉴定和量化人顺式异戊二烯基转移酶的膜相互作用。
Protein Sci. 2025 Jun;34(6):e70167. doi: 10.1002/pro.70167.
5
Regulation of synaptic function and lipid metabolism.突触功能与脂质代谢的调节。
Neural Regen Res. 2026 Mar 1;21(3):1037-1057. doi: 10.4103/NRR.NRR-D-24-01412. Epub 2025 Apr 29.
6
APCI-Multistage Mass Spectrometry Following Liquid Chromatography for Selected 4-Desmethyl-Sterols and Their Deuterium-Labelled Analogues Unveils Characteristic Fragmentation Routes for Cholesterol and Phytosterols Identification.液相色谱-大气压化学电离多级质谱法用于选定的4-去甲基甾醇及其氘代类似物,揭示了胆固醇和植物甾醇鉴定的特征性裂解途径。
Rapid Commun Mass Spectrom. 2025 Jul 15;39(13):e10039. doi: 10.1002/rcm.10039.
7
Comprehensive characterization of volatile terpenoids and terpene synthases in Lanxangia tsaoko.草果中挥发性萜类化合物和萜烯合酶的综合表征
Mol Hortic. 2025 Apr 3;5(1):20. doi: 10.1186/s43897-024-00140-0.
8
The Role of Cholesterol Metabolism and Its Regulation in Tumor Development.胆固醇代谢及其调节在肿瘤发生中的作用。
Cancer Med. 2025 Apr;14(7):e70783. doi: 10.1002/cam4.70783.
9
Targeting the isoprenoid pathway in choleste biosynthesis: An approach to identify isoprenoid biosynthesis inhibitors.靶向胆固醇生物合成中的类异戊二烯途径:一种鉴定类异戊二烯生物合成抑制剂的方法。
Arch Pharm (Weinheim). 2025 Feb;358(2):e2400807. doi: 10.1002/ardp.202400807.
10
The Liver X Receptor Promotes Immune Homeostasis via Controlled Activation of the Innate Immune System in the Liver.肝脏X受体通过对肝脏固有免疫系统的可控激活促进免疫稳态。
Biomolecules. 2024 Dec 28;15(1):25. doi: 10.3390/biom15010025.
剖析高等植物固醇 C-4 脱甲基化过程:从结构和基因到催化机制。
Steroids. 2011 Mar;76(4):340-52. doi: 10.1016/j.steroids.2010.11.011. Epub 2010 Dec 13.
4
Malformation syndromes caused by disorders of cholesterol synthesis.胆固醇合成障碍导致的畸形综合征。
J Lipid Res. 2011 Jan;52(1):6-34. doi: 10.1194/jlr.R009548. Epub 2010 Oct 7.
5
Coxiella burnetii expresses a functional Δ24 sterol reductase.贝纳柯克斯体表达一种功能性Δ24 固醇还原酶。
J Bacteriol. 2010 Dec;192(23):6154-9. doi: 10.1128/JB.00818-10. Epub 2010 Sep 24.
6
Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.烟曲霉甾醇 14-α 脱甲基酶(CYP51)同工酶 A 和 B 的表达、纯化和特性。
Antimicrob Agents Chemother. 2010 Oct;54(10):4225-34. doi: 10.1128/AAC.00316-10. Epub 2010 Jul 26.
7
Cloning, mechanistic and functional analysis of a fungal sterol C24-methyltransferase implicated in brassicasterol biosynthesis.参与油菜甾醇生物合成的真菌甾醇C24-甲基转移酶的克隆、机制及功能分析
Biochim Biophys Acta. 2010 Oct;1801(10):1163-74. doi: 10.1016/j.bbalip.2010.06.007. Epub 2010 Jul 17.
8
Type II isopentenyl diphosphate isomerase: probing the mechanism with alkyne/allene diphosphate substrate analogues.II 型异戊烯二磷酸异构酶:用炔烃/丙二烯二磷酸底物类似物探究其机理。
Biochemistry. 2010 Jul 27;49(29):6228-33. doi: 10.1021/bi100844e.
9
Phylogenetic distribution of fungal sterols.真菌甾醇的系统发生分布。
PLoS One. 2010 May 28;5(5):e10899. doi: 10.1371/journal.pone.0010899.
10
Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole.克氏锥虫和布氏冈比亚锥虫细胞色素 P45051 与抗真菌药物泊沙康唑和氟康唑结合的结构特征。
PLoS Negl Trop Dis. 2010 Apr 6;4(4):e651. doi: 10.1371/journal.pntd.0000651.