肯尼亚产后女性中C868T单核苷酸多态性与1型艾滋病病毒疾病进展情况
C868T single nucleotide polymorphism and HIV type 1 disease progression among postpartum women in Kenya.
作者信息
Choi Robert Y, Fowke Keith R, Juno Jennifer, Lohman-Payne Barbara, Oyugi Julius O, Brown Elizabeth R, Bosire Rose, John-Stewart Grace, Farquhar Carey
机构信息
Department of Medicine, University of Washington, Seattle, Washington 98104, USA.
出版信息
AIDS Res Hum Retroviruses. 2012 Jun;28(6):566-70. doi: 10.1089/AID.2011.0095. Epub 2011 Sep 27.
Abstract
The C868T single nucleotide polymorphism in the CD4 receptor encodes an amino acid substitution of tryptophan for arginine in the third domain. Previous studies suggest that C868T increases the risk of HIV-1 acquisition; however, the influence of this single nucleotide polymorphism (SNP) on disease progression has not been established. The presence of the C868T polymorphism was not statistically significantly associated with HIV-1 disease progression outcomes in a cohort of postpartum Kenyan women.
摘要
CD4受体中的C868T单核苷酸多态性在第三个结构域编码了一个将精氨酸替换为色氨酸的氨基酸替代。先前的研究表明，C868T会增加感染HIV-1的风险；然而，这种单核苷酸多态性（SNP）对疾病进展的影响尚未明确。在一组肯尼亚产后妇女中，C868T多态性的存在与HIV-1疾病进展结果在统计学上没有显著关联。
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