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J Virol. 2009 Dec;83(23):12636-42. doi: 10.1128/JVI.01236-09. Epub 2009 Sep 16.
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Maternal transmission of human immunodeficiency virus escape mutations subverts HLA-B57 immunodominance but facilitates viral control in the haploidentical infant.人类免疫缺陷病毒逃逸突变的母源性传播破坏了HLA - B57免疫显性，但有助于单倍体相合婴儿的病毒控制。
J Virol. 2009 Sep;83(17):8616-27. doi: 10.1128/JVI.00730-09. Epub 2009 Jun 10.
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肯尼亚产后女性中C868T单核苷酸多态性与1型艾滋病病毒疾病进展情况

C868T single nucleotide polymorphism and HIV type 1 disease progression among postpartum women in Kenya.

作者信息

Choi Robert Y, Fowke Keith R, Juno Jennifer, Lohman-Payne Barbara, Oyugi Julius O, Brown Elizabeth R, Bosire Rose, John-Stewart Grace, Farquhar Carey

机构信息

Department of Medicine, University of Washington, Seattle, Washington 98104, USA.

出版信息

AIDS Res Hum Retroviruses. 2012 Jun;28(6):566-70. doi: 10.1089/AID.2011.0095. Epub 2011 Sep 27.

DOI:10.1089/AID.2011.0095
PMID:21902583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3358105/
Abstract

The C868T single nucleotide polymorphism in the CD4 receptor encodes an amino acid substitution of tryptophan for arginine in the third domain. Previous studies suggest that C868T increases the risk of HIV-1 acquisition; however, the influence of this single nucleotide polymorphism (SNP) on disease progression has not been established. The presence of the C868T polymorphism was not statistically significantly associated with HIV-1 disease progression outcomes in a cohort of postpartum Kenyan women.

摘要

CD4受体中的C868T单核苷酸多态性在第三个结构域编码了一个将精氨酸替换为色氨酸的氨基酸替代。先前的研究表明，C868T会增加感染HIV-1的风险；然而，这种单核苷酸多态性（SNP）对疾病进展的影响尚未明确。在一组肯尼亚产后妇女中，C868T多态性的存在与HIV-1疾病进展结果在统计学上没有显著关联。