婴儿 CD4 C868T 多态性与人类免疫缺陷病毒（HIV-1）获得性增加有关。
Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition.
机构信息
Department of Medicine, University of Washington, Seattle, WA 98104, USA.
出版信息
Clin Exp Immunol. 2010 Jun;160(3):461-5. doi: 10.1111/j.1365-2249.2010.04096.x. Epub 2010 Feb 2.
Abstract
The C868T single nucleotide polymorphism (SNP) in the CD4 receptor encodes an amino acid change that could alter its structure and influence human immunodeficiency virus (HIV-1) infection risk. HIV-1-infected pregnant women in Nairobi were followed with their infants for 1 year postpartum. Among 131 infants, those with the 868T allele were more likely than wild-type infants to acquire HIV-1 overall [hazard ratio (HR) = 1.92, 95% confidence interval (CI) 1.05, 3.50, P = 0.03; adjusted HR = 2.03, 95% CI 1.03, 3.98, P = 0.04], after adjusting for maternal viral load. This SNP (an allele frequency of approximately 15% in our cohort) was associated with increased susceptibility to mother-to-child HIV-1 transmission, consistent with a previous study on this polymorphism among Nairobi sex workers.
摘要
C868T 单核苷酸多态性（SNP）在 CD4 受体中编码一个氨基酸变化，可能改变其结构并影响人类免疫缺陷病毒（HIV-1）感染风险。在内罗毕，对感染 HIV-1 的孕妇进行了为期 1 年的产后随访及其婴儿。在 131 名婴儿中，携带 868T 等位基因的婴儿比野生型婴儿更有可能总体上感染 HIV-1[风险比（HR）=1.92，95%置信区间（CI）1.05，3.50，P=0.03；调整后的 HR=2.03，95%CI 1.03，3.98，P=0.04]，这与母体病毒载量有关。在我们的队列中，这种 SNP（等位基因频率约为 15%）与母婴 HIV-1 传播的易感性增加有关，这与内罗毕性工作者中这项多态性的先前研究一致。
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本文引用的文献
1
A common CD4 gene variant is associated with an increased risk of HIV-1 infection in Kenyan female commercial sex workers.一种常见的CD4基因变体与肯尼亚女性商业性工作者感染HIV-1的风险增加有关。
J Infect Dis. 2009 May 1;199(9):1327-34. doi: 10.1086/597616.
2
Validation of performance of the gen-probe human immunodeficiency virus type 1 viral load assay with genital swabs and breast milk samples.使用生殖器拭子和母乳样本对基因探针1型人类免疫缺陷病毒病毒载量检测方法的性能验证。
J Clin Microbiol. 2002 Nov;40(11):3929-37. doi: 10.1128/JCM.40.11.3929-3937.2002.
3
Evaluation of performance of the Gen-Probe human immunodeficiency virus type 1 viral load assay using primary subtype A, C, and D isolates from Kenya.使用来自肯尼亚的原发性A、C和D亚型分离株对Gen-Probe 1型人类免疫缺陷病毒病毒载量检测方法的性能评估。
J Clin Microbiol. 2000 Jul;38(7):2688-95. doi: 10.1128/JCM.38.7.2688-2695.2000.
4
From research to practice: use of short course zidovudine to prevent mother-to-child HIV transmission in the context of routine health care in Northern Thailand.从研究到实践：在泰国北部常规医疗保健背景下使用齐多夫定短疗程预防母婴传播艾滋病毒。
Southeast Asian J Trop Med Public Health. 1998 Sep;29(3):429-42.
5
Rapid method for screening dried blood samples on filter paper for human immunodeficiency virus type 1 DNA.用于筛查滤纸上干燥血样中1型人类免疫缺陷病毒DNA的快速方法。
J Clin Microbiol. 1999 Feb;37(2):350-3. doi: 10.1128/JCM.37.2.350-353.1999.
6
Increased frequency of CCR-5 delta 32 heterozygotes among long-term non-progressors with HIV-1 infection. The Australian Long-Term Non-Progressor Study Group.HIV-1感染长期不进展者中CCR-5 delta 32杂合子频率增加。澳大利亚长期不进展者研究小组。
AIDS. 1997 Dec;11(15):1833-8. doi: 10.1097/00002030-199715000-00007.
7
The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.一种突变的CCR5等位基因在HIV-1传播和疾病进展中的作用。
Nat Med. 1996 Nov;2(11):1240-3. doi: 10.1038/nm1196-1240.
8
Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study.通过CKR5结构基因的一个缺失等位基因对HIV-1感染及向艾滋病进展的遗传限制。血友病生长与发育研究、多中心艾滋病队列研究、多中心血友病队列研究、旧金山城市队列、ALIVE研究。
Science. 1996 Sep 27;273(5283):1856-62. doi: 10.1126/science.273.5283.1856.
9
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection.HIV-1共受体的纯合缺陷导致一些多次暴露个体对HIV-1感染具有抗性。
Cell. 1996 Aug 9;86(3):367-77. doi: 10.1016/s0092-8674(00)80110-5.
10
Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.携带CCR-5趋化因子受体基因突变等位基因的白种人个体对HIV-1感染的抗性
Nature. 1996 Aug 22;382(6593):722-5. doi: 10.1038/382722a0.
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