Department of Medicine, University of Washington, Seattle, WA 98104, USA.
Clin Exp Immunol. 2010 Jun;160(3):461-5. doi: 10.1111/j.1365-2249.2010.04096.x. Epub 2010 Feb 2.
The C868T single nucleotide polymorphism (SNP) in the CD4 receptor encodes an amino acid change that could alter its structure and influence human immunodeficiency virus (HIV-1) infection risk. HIV-1-infected pregnant women in Nairobi were followed with their infants for 1 year postpartum. Among 131 infants, those with the 868T allele were more likely than wild-type infants to acquire HIV-1 overall [hazard ratio (HR) = 1.92, 95% confidence interval (CI) 1.05, 3.50, P = 0.03; adjusted HR = 2.03, 95% CI 1.03, 3.98, P = 0.04], after adjusting for maternal viral load. This SNP (an allele frequency of approximately 15% in our cohort) was associated with increased susceptibility to mother-to-child HIV-1 transmission, consistent with a previous study on this polymorphism among Nairobi sex workers.
C868T 单核苷酸多态性（SNP）在 CD4 受体中编码一个氨基酸变化，可能改变其结构并影响人类免疫缺陷病毒（HIV-1）感染风险。在内罗毕，对感染 HIV-1 的孕妇进行了为期 1 年的产后随访及其婴儿。在 131 名婴儿中，携带 868T 等位基因的婴儿比野生型婴儿更有可能总体上感染 HIV-1[风险比（HR）=1.92，95%置信区间（CI）1.05，3.50，P=0.03；调整后的 HR=2.03，95%CI 1.03，3.98，P=0.04]，这与母体病毒载量有关。在我们的队列中，这种 SNP（等位基因频率约为 15%）与母婴 HIV-1 传播的易感性增加有关，这与内罗毕性工作者中这项多态性的先前研究一致。
