Ghosh Sabyasachi, Chandran Arthi, Jansen Jeroen P
Mapi Values Boston, Massachusetts 02114, USA.
AIDS Res Hum Retroviruses. 2012 Jan;28(1):36-48. doi: 10.1089/AID.2011.0116. Epub 2011 Dec 22.
We sought to identify and summarize the incidence and prevalence of neuropathy among HIV patients and subgroups. A systematic search of the literature was performed using MEDLINE and EMBASE. The relevant literature was identified based on predefined criteria. Prevalence data were collected from cross-sectional and cohort studies. Incidence data were collected from cohort and case-control studies. Thirty-seven studies were included of which there were 23 cohort studies, 13 cross-sectional studies, and one case-control study. The prevalence of neuropathy among HIV patients derived from 25 studies varied from 1.2% to 69.4%. Regarding the development of neuropathy among HIV-positive patients, standardized by study duration, the rates per 100 person-years ranged from 0.7 to 39.7. Among older patients there is a greater risk of neuropathy. The same seems to be the case for patients with more severe disease. Currently available studies providing information on the incidence and prevalence of neuropathy among HIV patients suggest a significant burden, but there is a great variation in results across studies. There is no definitive explanation for the variation. However, it underscores the fact that complexity of the disease, along with absence of standardized diagnostic criteria, has considerably influenced the methodologies and outcomes of the studies.
我们试图确定并总结HIV患者及其亚组中神经病变的发病率和患病率。使用MEDLINE和EMBASE对文献进行了系统检索。根据预先设定的标准确定相关文献。患病率数据来自横断面研究和队列研究。发病率数据来自队列研究和病例对照研究。纳入了37项研究，其中有23项队列研究、13项横断面研究和1项病例对照研究。来自25项研究的HIV患者神经病变患病率在1.2%至69.4%之间。关于HIV阳性患者神经病变的发生情况，按研究持续时间标准化后，每100人年的发生率在0.7至39.7之间。老年患者患神经病变的风险更大。病情更严重的患者似乎也是如此。目前提供HIV患者神经病变发病率和患病率信息的研究表明负担较重，但各研究结果差异很大。对于这种差异没有确切的解释。然而，这凸显了这样一个事实，即疾病的复杂性以及缺乏标准化的诊断标准，极大地影响了研究方法和结果。
