Kanao-Kanda Megumi, Luthe Sarah Kyuragi, Onodera Yoshiko, Sato Izumi, Endo Tomoyuki, Kawamata Tomoyuki, Kanda Hirotsugu
Department of Anesthesiology, Wakayama Medical University School of Medicine, 811-1 Kimiidera, Wakayama, Wakayama, 641-8509, Japan.
Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
J Anesth. 2025 Apr 16. doi: 10.1007/s00540-025-03493-y.
Although human immunodeficiency virus (HIV)-related peripheral neuropathies are among the most common neurological complications in patients with HIV infection, the prevalence and patient characteristics of HIV-related pain and peripheral neuropathic pain in Japan remain unclear.
This study aims to investigate the prevalence and patient characteristics of HIV-related pain with a focus on peripheral neuropathic pain among Japanese patients.
We conducted a survey among patients diagnosed with HIV infection and reviewed their medical records to collect the following information; age, sex, presence of pain or numbness, duration of pain or numbness, duration of HIV infection, clusters of differentiation 4 (CD4) T-cell count, ribonucleic acid (RNA) load, diagnosis and duration of acquired immune deficiency syndrome (AIDS), treatment status and duration of highly active antiretroviral therapy (HAART). The primary outcome of this study was the prevalence of HIV-related pain with a focus on peripheral neuropathic pain.
A survey was distributed to 474 patients, of whom 270 chose not to participate. Consequently, data from 204 patients were included in the analysis. The prevalence of HIV-related pain was 16% and patients with possible HIV-related peripheral neuropathic pain was 9.3%. Among these patients, age, presence of numbness, duration of numbness, and duration of AIDS were significantly higher than in patients without HIV-related pain.
In this prospective multi-center cross-sectional study, the prevalence of HIV-related pain was 16% among 204 Japanese patients with HIV in which they tended to have advanced age and longer duration of AIDS compared to patients without HIV-related pain.
尽管人类免疫缺陷病毒（HIV）相关的周围神经病变是HIV感染患者中最常见的神经并发症之一，但日本HIV相关疼痛和周围神经病理性疼痛的患病率及患者特征仍不清楚。
本研究旨在调查日本患者中以周围神经病理性疼痛为重点的HIV相关疼痛的患病率及患者特征。
我们对诊断为HIV感染的患者进行了一项调查，并查阅他们的病历以收集以下信息：年龄、性别、疼痛或麻木的存在情况、疼痛或麻木的持续时间、HIV感染的持续时间、分化簇4（CD4）T细胞计数、核糖核酸（RNA）载量、获得性免疫缺陷综合征（AIDS）的诊断及持续时间、治疗状态及高效抗逆转录病毒治疗（HAART）的持续时间。本研究的主要结局是以周围神经病理性疼痛为重点的HIV相关疼痛的患病率。
向474名患者发放了调查问卷，其中270人选择不参与。因此，分析纳入了204名患者的数据。HIV相关疼痛的患病率为16%，可能患有HIV相关周围神经病理性疼痛的患者为9.3%。在这些患者中，年龄、麻木的存在情况、麻木的持续时间和AIDS的持续时间显著高于无HIV相关疼痛的患者。
在这项前瞻性多中心横断面研究中，204名日本HIV患者中HIV相关疼痛的患病率为16%，与无HIV相关疼痛的患者相比，他们往往年龄较大且AIDS持续时间较长。
