Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Curr Pharm Des. 2011;17(31):3374-80. doi: 10.2174/138161211798072562.
Mitochondrial dynamics play a crucial role in the pathobiology underlying Alzheimer's disease (AD) and Parkinson's disease (PD). Although a complete scientific understanding of these devastating conditions has yet to be realized, alterations in mitochondrial fission and fusion, and in the protein complexes that orchestrate mitochondrial fission and fusion, have been well established in AD- and PD-related neurodegeneration. Whether fission/fusion disruption in the brain is a causal agent in neuronal demise or a product of some other upstream disturbance is still a matter of debate; however, in both AD and PD, the potential for successful therapeutic amelioration of degeneration via mitochondrial protection is high. We here discuss the role of mitochondrial dynamics in AD and PD and assess the need for their therapeutic exploitation.
线粒体动态在阿尔茨海默病（AD）和帕金森病（PD）的病理生物学中起着至关重要的作用。尽管人们尚未完全了解这些破坏性疾病，但在 AD 和 PD 相关的神经退行性变中，线粒体分裂和融合以及协调线粒体分裂和融合的蛋白质复合物的改变已经得到了很好的证实。在大脑中，分裂/融合的破坏是神经元死亡的原因还是其他上游干扰的产物，这仍然是一个有争议的问题；然而，在 AD 和 PD 中，通过线粒体保护来成功治疗退化的潜力很高。我们在这里讨论了线粒体动态在 AD 和 PD 中的作用，并评估了对其进行治疗性利用的必要性。
