墨西哥患者 Toll 样受体 2 和 4 基因多态性的低频与 2 型糖尿病的相关性。
Low frequency of Toll-like receptors 2 and 4 gene polymorphisms in Mexican patients and their association with type 2 diabetes.
机构信息
Hospital de Pediatría, Centro Médico Nacional SXXI, IMSS, México City, México.
出版信息
Int J Immunogenet. 2011 Dec;38(6):519-23. doi: 10.1111/j.1744-313X.2011.01035.x. Epub 2011 Sep 9.
Abstract
Type 2 diabetes (T2D) is characterized by a chronic low-grade inflammatory state. SNP in Toll-like receptor (TLR) genes has been associated with impaired inflammatory response. We genotyped the TLR4/D299G, TLR4/T399I and TLR2/R753Q polymorphisms. Low frequency was found with no association with T2D, nevertheless the TLR2 SNP was associated with lower levels in HDL-cholesterol values.
摘要
2 型糖尿病（T2D）的特征是慢性低度炎症状态。Toll 样受体（TLR）基因的 SNP 与炎症反应受损有关。我们对 TLR4/D299G、TLR4/T399I 和 TLR2/R753Q 多态性进行了基因分型。结果发现低频 SNP 与 T2D 无关，但 TLR2 SNP 与 HDL-胆固醇水平降低有关。
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