• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

墨西哥患者 Toll 样受体 2 和 4 基因多态性的低频与 2 型糖尿病的相关性。

Low frequency of Toll-like receptors 2 and 4 gene polymorphisms in Mexican patients and their association with type 2 diabetes.

机构信息

Hospital de Pediatría, Centro Médico Nacional SXXI, IMSS, México City, México.

出版信息

Int J Immunogenet. 2011 Dec;38(6):519-23. doi: 10.1111/j.1744-313X.2011.01035.x. Epub 2011 Sep 9.

DOI:10.1111/j.1744-313X.2011.01035.x
PMID:21902816
Abstract

Type 2 diabetes (T2D) is characterized by a chronic low-grade inflammatory state. SNP in Toll-like receptor (TLR) genes has been associated with impaired inflammatory response. We genotyped the TLR4/D299G, TLR4/T399I and TLR2/R753Q polymorphisms. Low frequency was found with no association with T2D, nevertheless the TLR2 SNP was associated with lower levels in HDL-cholesterol values.

摘要

2 型糖尿病（T2D）的特征是慢性低度炎症状态。Toll 样受体（TLR）基因的 SNP 与炎症反应受损有关。我们对 TLR4/D299G、TLR4/T399I 和 TLR2/R753Q 多态性进行了基因分型。结果发现低频 SNP 与 T2D 无关，但 TLR2 SNP 与 HDL-胆固醇水平降低有关。

相似文献

1
Low frequency of Toll-like receptors 2 and 4 gene polymorphisms in Mexican patients and their association with type 2 diabetes.墨西哥患者 Toll 样受体 2 和 4 基因多态性的低频与 2 型糖尿病的相关性。
Int J Immunogenet. 2011 Dec;38(6):519-23. doi: 10.1111/j.1744-313X.2011.01035.x. Epub 2011 Sep 9.
2
No association of TLR2 and TLR4 polymorphisms with type I diabetes mellitus in the Basque population.在巴斯克人群中，TLR2和TLR4基因多态性与I型糖尿病无关联。
Ann N Y Acad Sci. 2006 Oct;1079:268-72. doi: 10.1196/annals.1375.040.
3
[Toll-like receptor 2 R753Q polymorphisms are associated with an increased risk of infective endocarditis].Toll样受体2 R753Q基因多态性与感染性心内膜炎风险增加相关
Rev Esp Cardiol. 2011 Nov;64(11):1056-9. doi: 10.1016/j.recesp.2011.02.024. Epub 2011 Jul 23.
4
Genetic variation of toll-like receptor genes and infection by Mycobacterium avium ssp. paratuberculosis in Holstein-Friesian cattle.奶牛中 TLR 基因的遗传变异与分支杆菌感染
J Dairy Sci. 2011 Jul;94(7):3635-41. doi: 10.3168/jds.2010-3788.
5
TLR4 single-nucleotide polymorphisms alter mucosal cytokine and chemokine patterns in Mexican patients with Helicobacter pylori-associated gastroduodenal diseases.Toll样受体4单核苷酸多态性改变墨西哥幽门螺杆菌相关性胃十二指肠疾病患者的黏膜细胞因子和趋化因子模式。
Clin Immunol. 2008 Nov;129(2):333-40. doi: 10.1016/j.clim.2008.07.009. Epub 2008 Aug 27.
6
Significant association between toll-like receptor gene polymorphisms and gallbladder cancer.胆囊癌与 toll 样受体基因多态性存在显著相关性。
Liver Int. 2010 Aug;30(7):1067-72. doi: 10.1111/j.1478-3231.2010.02268.x. Epub 2010 May 14.
7
TLR2 Arg753Gly, TLR4 Asp299Gly and Thr399Ile gene polymorphisms are not associated with chronic periodontitis in a Turkish population.TLR2基因的Arg753Gly、TLR4基因的Asp299Gly和Thr399Ile基因多态性与土耳其人群的慢性牙周炎无关。
J Clin Periodontol. 2007 Jul;34(7):551-7. doi: 10.1111/j.1600-051X.2007.01092.x.
8
Association of TLR2 and TLR4 non-missense single nucleotide polymorphisms with type 2 diabetes risk in a southern Chinese population: a case-control study.TLR2和TLR4非同义单核苷酸多态性与中国南方人群2型糖尿病风险的关联：一项病例对照研究
Genet Mol Res. 2015 Jul 31;14(3):8694-705. doi: 10.4238/2015.July.31.18.
9
Association studies of gene polymorphisms in toll-like receptors 2 and 4 in Croatian patients with acute myocardial infarction.急性心肌梗死的克罗地亚患者中 Toll 样受体 2 和 4 基因多态性的关联研究。
Scand J Immunol. 2012 May;75(5):517-23. doi: 10.1111/j.1365-3083.2012.02681.x.
10
Relationship between toll-like receptor 2 Arg677Trp and Arg753Gln and toll-like receptor 4 Asp299Gly polymorphisms and cytomegalovirus infection.Toll样受体2的Arg677Trp和Arg753Gln多态性、Toll样受体4的Asp299Gly多态性与巨细胞病毒感染之间的关系。
Int J Infect Dis. 2014 Aug;25:11-5. doi: 10.1016/j.ijid.2014.04.001. Epub 2014 May 9.

引用本文的文献

1
Allelic, Genotypic, and Haplotypic Analysis of Cytokine IL17A, IL17F, and Toll-like Receptor TLR4 Gene Polymorphisms in Metabolic-Dysfunction-Associated Steatotic Liver Disease: Insights from an Exploratory Study.代谢功能障碍相关脂肪性肝病中细胞因子IL17A、IL17F和Toll样受体TLR4基因多态性的等位基因、基因型和单倍型分析：一项探索性研究的见解
Life (Basel). 2024 Oct 18;14(10):1327. doi: 10.3390/life14101327.
2
Toll-Like Receptor 2 (TLR-2) Gene Polymorphisms in Type 2 Diabetes Mellitus.2型糖尿病中的Toll样受体2（TLR-2）基因多态性
Cell J. 2019 Jan;20(4):559-563. doi: 10.22074/cellj.2019.5540. Epub 2018 Aug 1.
3
Genetic Epidemiology of Type 2 Diabetes in Mexican Mestizos.
墨西哥梅斯蒂索人2型糖尿病的遗传流行病学
Biomed Res Int. 2017;2017:3937893. doi: 10.1155/2017/3937893. Epub 2017 May 18.
4
Toll-like receptor 2 and type 2 diabetes.Toll样受体2与2型糖尿病
Cell Mol Biol Lett. 2016 Jul 28;21:2. doi: 10.1186/s11658-016-0002-4. eCollection 2016.
5
Genetic Variants in Toll-Like Receptor 4 Gene and Their Association Analysis with Estimated Glomerular Filtration Rate in Mexican American Families.墨西哥裔美国家庭中Toll样受体4基因的遗传变异及其与估计肾小球滤过率的关联分析
Cardiorenal Med. 2016 Aug;6(4):301-6. doi: 10.1159/000445754. Epub 2016 May 20.
6
Association between Toll-Like Receptor 4 and Occurrence of Type 2 Diabetes Mellitus Susceptible to Pulmonary Tuberculosis in Northeast China.中国东北地区Toll样受体4与易患肺结核的2型糖尿病发生之间的关联
Stem Cells Int. 2016;2016:8160318. doi: 10.1155/2016/8160318. Epub 2016 Mar 31.
7
Impaired CD4+ and T-helper 17 cell memory response to Streptococcus pneumoniae is associated with elevated glucose and percent glycated hemoglobin A1c in Mexican Americans with type 2 diabetes mellitus.墨西哥裔 2 型糖尿病患者中，葡萄糖和糖化血红蛋白 A1c 百分率升高与肺炎链球菌 CD4+和 T 辅助细胞 17 记忆应答受损有关。
Transl Res. 2014 Jan;163(1):53-63. doi: 10.1016/j.trsl.2013.07.005. Epub 2013 Aug 5.
8
Toll-like receptor 4 D299G polymorphism in metabolic disorders: a meta-analysis.Toll 样受体 4 D299G 多态性与代谢紊乱：荟萃分析。
Mol Biol Rep. 2013 Apr;40(4):3015-20. doi: 10.1007/s11033-012-2374-5. Epub 2012 Dec 29.
9
Association of toll-like receptor 4 polymorphisms with type 2 diabetes mellitus.Toll 样受体 4 多态性与 2 型糖尿病的关联。
Inflammation. 2013 Feb;36(1):251-7. doi: 10.1007/s10753-012-9541-7.