van den Wall Bake A W, Daha M R, van Es L A
Afd. Nierziekten, gebouw I, C3P, Academisch Ziekenhuis, Leiden.
Tijdschr Kindergeneeskd. 1990 Apr;58(2):55-9.
The pathogenesis of IgA nephropathy has remained elusive in the twenty years that have passed since the first description of the disease. Based on the recent literature, we present a pathogenetic model in which a primary disorder of immune regulation plays a central role. This disorder of immune regulation results in an increased synthesis of plasma IgAI antibodies by the bone marrow, in response to everyday mucosal infections. Through an unknown mechanism, these circulating IgAI antibodies deposit in the mesangium, and cause an inflammatory response.
自首次描述IgA肾病以来的二十年里，其发病机制一直不明确。基于最近的文献，我们提出一种发病机制模型，其中免疫调节的原发性紊乱起着核心作用。这种免疫调节紊乱导致骨髓针对日常黏膜感染增加血浆IgA1抗体的合成。通过一种未知机制，这些循环的IgA1抗体沉积于系膜，并引发炎症反应。
