Research Unit on Biomedical Informatics, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Dr Aiguader 88, 08003 Barcelona, Spain.
Database (Oxford). 2011 Sep 7;2011:bar039. doi: 10.1093/database/bar039. Print 2011.
Recently, we created IntOGen, a resource to integrate a large amount of cancer genomic data. IntOGen aims at facilitating the detection of the most recurrent alterations that drive tumorigenesis. It collates, annotates and analyzes high-throughput data about transcriptional, genomic and mutational changes taking place in tumors from different studies annotated with specific cancer types. Currently, it contains 118 studies for mRNA expression profiling and 188 studies for genomic alterations covering in total 64 different tumor topographies. In this article, we describe the Biomart portal for IntOGen. The portal provides easy access to different types of data and facilitates the bulk download of all the analysis results. Here, we describe the general features of IntOGen and give example queries to demonstrate its use. Database URL: www.intogen.org.
最近，我们创建了 IntOGen，这是一个整合大量癌症基因组数据的资源。IntOGen 的目的是促进对驱动肿瘤发生的最常见改变的检测。它整理、注释和分析了来自不同研究的关于肿瘤中转录组、基因组和突变变化的高通量数据，这些研究都用特定的癌症类型进行了注释。目前，它包含了 118 项关于 mRNA 表达谱的研究和 188 项关于基因组改变的研究，总共涵盖了 64 种不同的肿瘤形态。在本文中，我们描述了 IntOGen 的 Biomart 门户。该门户提供了对不同类型数据的便捷访问，并方便批量下载所有分析结果。在这里，我们描述了 IntOGen 的一般特征，并给出了示例查询来演示其使用方法。数据库网址：www.intogen.org。
